About: Ghrelin agonists impact on Fos protein expression in brain areas related to food intake regulation in male C57BL/6 mice

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Many peripheral substances, including ghrelin, induce neuronal activation in the brain. In the present study, we compared the effect of subcutaneously administered ghrelin and its three stable analogues, agonists: Dpr3ghr ([Dpr(N-octanoyl)3] ghrelin) (Dpr – diaminopropionic acid), YA GHRP-6 (Tyr-Ala-His-DTrp-Ala-Trp-DPhe-Lys-NH2), and JMV1843 (H-Aib-DTrp-D-gTrp-CHO) on the Fos expression in food intake-responsive brain areas such as the hypothalamic paraventricular (PVN) and arcuate (ARC) nuclei, the nucleus of the solitary tract (NTS), and area postrena (AP) in male C57BL/6 mice. Immunohistochemical analysis showed that acute SC administration of each of these substances, in dose (5 mg/kg b.w.), which induce strong food intake increase, elevated Fos protein expression in all brain areas studied. Many peripheral substances, including ghrelin, induce neuronal activation in the brain. In the present study, we compared the effect of subcutaneously administered ghrelin and its three stable analogues, agonists: Dpr3ghr ([Dpr(N-octanoyl)3] ghrelin) (Dpr – diaminopropionic acid), YA GHRP-6 (Tyr-Ala-His-DTrp-Ala-Trp-DPhe-Lys-NH2), and JMV1843 (H-Aib-DTrp-D-gTrp-CHO) on the Fos expression in food intake-responsive brain areas such as the hypothalamic paraventricular (PVN) and arcuate (ARC) nuclei, the nucleus of the solitary tract (NTS), and area postrena (AP) in male C57BL/6 mice. Immunohistochemical analysis showed that acute SC administration of each of these substances, in dose (5 mg/kg b.w.), which induce strong food intake increase, elevated Fos protein expression in all brain areas studied. (en)
Title	Ghrelin agonists impact on Fos protein expression in brain areas related to food intake regulation in male C57BL/6 mice Ghrelin agonists impact on Fos protein expression in brain areas related to food intake regulation in male C57BL/6 mice (en)
skos:prefLabel	Ghrelin agonists impact on Fos protein expression in brain areas related to food intake regulation in male C57BL/6 mice Ghrelin agonists impact on Fos protein expression in brain areas related to food intake regulation in male C57BL/6 mice (en)
skos:notation	RIV/61388963:_____/11:00366099!RIV12-AV0-61388963
http://linked.open...avai/predkladatel	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA303/09/0744), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Pýchová, Miroslava Maletínská, Lenka Železná, Blanka Holubová, Martina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	201270
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/11:00366099
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ghrelin agonists; Fos immunohistochemistry; male C57BL/6 mice (en)
http://linked.open.../riv/klicoveSlovo	Fos immunohistochemistry ghrelin agonists male C57BL/6 mice
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[7061890C9CF0]
http://linked.open...i/riv/nazevZdroje	Neurochemistry International
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Impact of ghrelin and estrogen on metabolic syndrom of female obese mice
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	59
http://linked.open...iv/tvurceVysledku	Maletínská, Lenka Martinez, J. Pýchová, Miroslava Železná, Blanka Kiss, A. Bundziková, J. Fehrentz, J. A. Holubová, Martina Pirnik, Z.
http://linked.open...ain/vavai/riv/wos	000297400700017
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	0197-0186
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.neuint.2011.08.001
is http://linked.open...avai/riv/vysledek of	Ghrelin agonists impact on Fos protein expression in brain areas related to food intake regulation in male C57BL/6 mice Ghrelin agonists impact on Fos protein expression in brain areas related to food intake regulation in male C57BL/6 mice

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