About: Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni

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About: Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We determined three crystal structures of Schistosoma mansoni cathepsin B1 (SmCB1) in complex with peptidomimetic inhibitors. A panel of vinyl sulfone inhibitors was screened in vitro with SmCB1 and in a schistosomula assay; severity of phenotype induced in the parasite correlated with enzyme inhibition. Substrate specificity of SmCB1 was analyzed using synthetic peptides and the natural substrate, hemoglobin. We determined three crystal structures of Schistosoma mansoni cathepsin B1 (SmCB1) in complex with peptidomimetic inhibitors. A panel of vinyl sulfone inhibitors was screened in vitro with SmCB1 and in a schistosomula assay; severity of phenotype induced in the parasite correlated with enzyme inhibition. Substrate specificity of SmCB1 was analyzed using synthetic peptides and the natural substrate, hemoglobin. (en)
Title	Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni (en)
skos:prefLabel	Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni (en)
skos:notation	RIV/61388963:_____/11:00365166!RIV12-AV0-61388963
http://linked.open...avai/predkladatel	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GA203/09/1585), P(GAP208/11/0295), P(OC09007), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	41
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Řezáčová, Pavlína Brynda, Jiří Mareš, Michael Horn, Martin Fanfrlík, Jindřich Jílková, Adéla Lepšík, Martin Váchová, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	232730
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/11:00365166
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cathepsin B; schistosoma; crystal structure (en)
http://linked.open.../riv/klicoveSlovo	cathepsin B schistosoma crystal structure
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[FD744143F637]
http://linked.open...i/riv/nazevZdroje	Journal of Biological Chemistry
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Parasite-targeted peptidase inhibitors as a tool for schistosomiasis therapy. In silico drug design based on advanced semiempirical quantum mechanical methods accurately describing noncovalent interactions Functional proteomics of plant defense proteins
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	286
http://linked.open...iv/tvurceVysledku	Brynda, Jiří Horn, Martin Lepšík, Martin Mareš, Michael Řezáčová, Pavlína Fanfrlík, Jindřich Caffrey, C. R. McKerrow, J. H. Jílková, Adéla Váchová, Jana
http://linked.open...ain/vavai/riv/wos	000295927100050
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	0021-9258
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1074/jbc.M111.271304
is http://linked.open...avai/riv/vysledek of	Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni

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