About: SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Coxsackievirus and related enteroviruses are important human pathogens that cause various diseases with clinical manifestations ranging from trivial flu-like syndromes to dangerous or even fatal diseases such as myocarditis, meningitis and encephalitis. Here, we report on our continuous SAR study focused on 9-(bicyclo[2.2.1]hept-2-yl)-9H-purines as anti-enteroviral inhibitors. The purine moiety was modified at positions 2, 6 and 8. Several analogues inhibited coxsackievirus B3 as well as other enteroviruses at low-micromolar concentrations. The 6-chloropurine derivative was confirmed as the most active compound in this series. Coxsackievirus and related enteroviruses are important human pathogens that cause various diseases with clinical manifestations ranging from trivial flu-like syndromes to dangerous or even fatal diseases such as myocarditis, meningitis and encephalitis. Here, we report on our continuous SAR study focused on 9-(bicyclo[2.2.1]hept-2-yl)-9H-purines as anti-enteroviral inhibitors. The purine moiety was modified at positions 2, 6 and 8. Several analogues inhibited coxsackievirus B3 as well as other enteroviruses at low-micromolar concentrations. The 6-chloropurine derivative was confirmed as the most active compound in this series. (en)
Title	SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors (en)
skos:prefLabel	SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors (en)
skos:notation	RIV/61388963:_____/11:00360813!RIV12-AV0-61388963
http://linked.open...avai/predkladatel	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0508), P(GAP303/11/1297), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	14
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Dračínský, Martin Hřebabecký, Hubert Nencka, Radim Mertlíková-Kaiserová, Helena Dejmek, Milan Šála, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	228144
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/11:00360813
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	coxsackievirus; norbornane; picornaviruses (en)
http://linked.open.../riv/klicoveSlovo	coxsackievirus norbornane picornaviruses
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[E88B5A9CF7A5]
http://linked.open...i/riv/nazevZdroje	Bioorganic and Medicinal Chemistry Letters
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Mechanisms of antiviral and cytostatic effects of novel carbocyclic nucleoside analogs New Antivirals and Antineoplastics
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	21
http://linked.open...iv/tvurceVysledku	Dračínský, Martin Dejmek, Milan Hřebabecký, Hubert Leyssen, P. Mertlíková-Kaiserová, Helena Nencka, Radim Neyts, J. Šála, Michal De Palma, A. M.
http://linked.open...ain/vavai/riv/wos	000292186400033
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	0960-894X
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.bmcl.2011.05.070
is http://linked.open...avai/riv/vysledek of	SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software