About: The synthesis of piperidine nucleoside analogs-a comparison of several methods to access the introduction of nucleobases

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	This work deals with the synthesis of piperidine and hydroxypiperidine analogs of nucleosides. Starting from commercially available 3-hydroxypiperidine, proline or 4-hydroxyproline, a series of piperidine derivatives of both purine and pyrimidine nucleobases was prepared. Various methods of nucleobase attachment were evaluated. The prepared compounds were tested for cytostatic, antibacterial, and antiviral properties but no significant activity was found. This work deals with the synthesis of piperidine and hydroxypiperidine analogs of nucleosides. Starting from commercially available 3-hydroxypiperidine, proline or 4-hydroxyproline, a series of piperidine derivatives of both purine and pyrimidine nucleobases was prepared. Various methods of nucleobase attachment were evaluated. The prepared compounds were tested for cytostatic, antibacterial, and antiviral properties but no significant activity was found. (en)
Title	The synthesis of piperidine nucleoside analogs-a comparison of several methods to access the introduction of nucleobases The synthesis of piperidine nucleoside analogs-a comparison of several methods to access the introduction of nucleobases (en)
skos:prefLabel	The synthesis of piperidine nucleoside analogs-a comparison of several methods to access the introduction of nucleobases The synthesis of piperidine nucleoside analogs-a comparison of several methods to access the introduction of nucleobases (en)
skos:notation	RIV/61388963:_____/11:00359135!RIV12-MZ0-61388963
http://linked.open...avai/predkladatel	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(2B06065), P(LC06077), P(NR9138), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Dračínský, Martin Rejman, Dominik Kovačková, Soňa
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	233913
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/11:00359135
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	piperidine derivatives; nucleoside analogs; nucleobase; proline (en)
http://linked.open.../riv/klicoveSlovo	nucleobase nucleoside analogs piperidine derivatives proline
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[BAB815F1A49D]
http://linked.open...i/riv/nazevZdroje	Tetrahedron
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	New Generation of Antibacterial Agens Inhibitors of Bacterial RNA Polymerase Based on Nucleotide Analogues Center of Chemical Genetics
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	67
http://linked.open...iv/tvurceVysledku	Dračínský, Martin Kovačková, Soňa Rejman, Dominik
http://linked.open...ain/vavai/riv/wos	000287340600013
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	0040-4020
number of pages	16 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.tet.2010.12.029
is http://linked.open...avai/riv/vysledek of	The synthesis of piperidine nucleoside analogs-a comparison of several methods to access the introduction of nucleobases The synthesis of piperidine nucleoside analogs-a comparison of several methods to access the introduction of nucleobases

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