About: Attenuation of vaccinia virus by the expression of human Flt3 ligand

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The expression of Flt3 ligand (FL) by recombinant vaccinia virus (rVACV) highly influenced properties of the virus in dependence on the level of expression. High production of FL driven by the strong synthetic promoter decreased the growth of rVACV in macrophage cell line J774.G8 in vitro as well as its multiplication in vivo when inoculated in mice. The inhibition of replication in vivo was mirrored in low levels of antibodies against vaccinia virus (anti-VACV) which nearly approached to the negative serum level in non-infected mice. Strong FL expression changed not only the host range of the recombinant but also the basic protein contents of virions. The major proteins - H3L and D8L - which are responsible for the virus binding to the cells, and 28 K protein that serves as a virulence factor, were changed in the membrane portion of P13-E/L-FL viral particles. The expression of Flt3 ligand (FL) by recombinant vaccinia virus (rVACV) highly influenced properties of the virus in dependence on the level of expression. High production of FL driven by the strong synthetic promoter decreased the growth of rVACV in macrophage cell line J774.G8 in vitro as well as its multiplication in vivo when inoculated in mice. The inhibition of replication in vivo was mirrored in low levels of antibodies against vaccinia virus (anti-VACV) which nearly approached to the negative serum level in non-infected mice. Strong FL expression changed not only the host range of the recombinant but also the basic protein contents of virions. The major proteins - H3L and D8L - which are responsible for the virus binding to the cells, and 28 K protein that serves as a virulence factor, were changed in the membrane portion of P13-E/L-FL viral particles. (en)
Title	Attenuation of vaccinia virus by the expression of human Flt3 ligand Attenuation of vaccinia virus by the expression of human Flt3 ligand (en)
skos:prefLabel	Attenuation of vaccinia virus by the expression of human Flt3 ligand Attenuation of vaccinia virus by the expression of human Flt3 ligand (en)
skos:notation	RIV/61388963:_____/10:00353377!RIV11-AV0-61388963
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NR9238), P(NS10660), Z(AV0Z40550506), Z(MZ0UHKT2005)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Šanda, Miloslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	248073
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/10:00353377
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	vaccinia virus; antibodies; virulence (en)
http://linked.open.../riv/klicoveSlovo	antibodies vaccinia virus virulence
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[97125351A062]
http://linked.open...i/riv/nazevZdroje	Virology Journal
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of experimental vaccine against WT 1 for immunotherapy of tumors Vectors for gene therapy targeted on stromal cells of solid tumors
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Šanda, Miloslav Žurková, K. Hainz, P. Kryštofová, J. Kutinová, L. Němečková, Š.
http://linked.open...ain/vavai/riv/wos	000279552600004
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství Význam molekulárně biologických vyšetření pro objasnění patogeneze a pro diagnostiku poruch krvetvorby a využití krvetvorné buňky v léčbě onemocnění krvetvorby a jiných tkání.
issn	1743-422X
number of pages	15 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Attenuation of vaccinia virus by the expression of human Flt3 ligand Attenuation of vaccinia virus by the expression of human Flt3 ligand Attenuation of vaccinia virus by the expression of human Flt3 ligand

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