About: Determination of doxazosin and verapamil in human serum by fast LC-MS/MS: Application to document non-compliance of patients

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About: Determination of doxazosin and verapamil in human serum by fast LC-MS/MS: Application to document non-compliance of patients Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A rapid and sensitive method using liquid chromatography–tandem mass spectrometry for simultaneous determination of doxazosin and verapamil in human serum has been developed. Trimipramine-d3 as an isotopic labelled internal standard was used for quantification. Serum samples were prepared by simple liquid–liquid extraction with mixture of tert butyl methyl ether and ethyl acetate. The analytes and internal standard were separated on C18 column using an isocratic elution. Positive TurboIonSpray mass spectrometry was used with multiple reaction monitoring of the transitions. An extensive pre-study method validation was carried out in accordance with FDA guidelines. This assay was successfully applied to determine the serum concentrations of doxazosin and verapamil in suspect non-compliance patients. A rapid and sensitive method using liquid chromatography–tandem mass spectrometry for simultaneous determination of doxazosin and verapamil in human serum has been developed. Trimipramine-d3 as an isotopic labelled internal standard was used for quantification. Serum samples were prepared by simple liquid–liquid extraction with mixture of tert butyl methyl ether and ethyl acetate. The analytes and internal standard were separated on C18 column using an isocratic elution. Positive TurboIonSpray mass spectrometry was used with multiple reaction monitoring of the transitions. An extensive pre-study method validation was carried out in accordance with FDA guidelines. This assay was successfully applied to determine the serum concentrations of doxazosin and verapamil in suspect non-compliance patients. (en)
Title	Determination of doxazosin and verapamil in human serum by fast LC-MS/MS: Application to document non-compliance of patients Determination of doxazosin and verapamil in human serum by fast LC-MS/MS: Application to document non-compliance of patients (en)
skos:prefLabel	Determination of doxazosin and verapamil in human serum by fast LC-MS/MS: Application to document non-compliance of patients Determination of doxazosin and verapamil in human serum by fast LC-MS/MS: Application to document non-compliance of patients (en)
skos:notation	RIV/61388963:_____/10:00352169!RIV11-AV0-61388963
http://linked.open...avai/riv/aktivita	I Z
http://linked.open...avai/riv/aktivity	I, Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	30
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Cvačka, Josef
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	253740
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/10:00352169
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	doxazosin; verapamil; hypertension (en)
http://linked.open.../riv/klicoveSlovo	hypertension - ischaemic heart disease - cardiac failure - vitamin D verapamil doxazosin
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[D93E77F5F48B]
http://linked.open...i/riv/nazevZdroje	Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	878
http://linked.open...iv/tvurceVysledku	Cvačka, Josef Widimský jr., J. Holaj, R. Marešová, V. Chytil, L. Štrauch, B. Slanař, O.
http://linked.open...ain/vavai/riv/wos	000284672300018
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	1570-0232
number of pages	7 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Determination of doxazosin and verapamil in human serum by fast LC-MS/MS: Application to document non-compliance of patients Determination of doxazosin and verapamil in human serum by fast LC-MS/MS: Application to document non-compliance of patients Determination of doxazosin and verapamil in human serum by fast LC-MS/MS: Application to document non-compliance of patients

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