About: Structural and molecular mechanism for autoprocessing of MARTX toxin of Vibrio cholerae at multiple sites

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The multifunctional autoprocessing repeats-in-toxin (MARTX) toxin of Vibrio cholerae causes destruction of the actin cytoskeleton by covalent cross-linking of actin and inactivation of Rho GTPases. The effector domains responsible for these activities are here shown to be independent proteins released from the large toxin by autoproteolysis catalyzed by an embedded cysteine protease domain (CPD). The CPD is activated upon binding inositol hexakisphosphate (InsP6). In this study, we demonstrated that InsP6 is not simply an allosteric cofactor, but rather binding of InsP6 stabilized the CPD structure, facilitating formation of the enzyme-substrate complex. The multifunctional autoprocessing repeats-in-toxin (MARTX) toxin of Vibrio cholerae causes destruction of the actin cytoskeleton by covalent cross-linking of actin and inactivation of Rho GTPases. The effector domains responsible for these activities are here shown to be independent proteins released from the large toxin by autoproteolysis catalyzed by an embedded cysteine protease domain (CPD). The CPD is activated upon binding inositol hexakisphosphate (InsP6). In this study, we demonstrated that InsP6 is not simply an allosteric cofactor, but rather binding of InsP6 stabilized the CPD structure, facilitating formation of the enzyme-substrate complex. (en)
Title	Structural and molecular mechanism for autoprocessing of MARTX toxin of Vibrio cholerae at multiple sites Structural and molecular mechanism for autoprocessing of MARTX toxin of Vibrio cholerae at multiple sites (en)
skos:prefLabel	Structural and molecular mechanism for autoprocessing of MARTX toxin of Vibrio cholerae at multiple sites Structural and molecular mechanism for autoprocessing of MARTX toxin of Vibrio cholerae at multiple sites (en)
skos:notation	RIV/61388963:_____/09:00336360!RIV10-AV0-61388963
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	39
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Voburka, Zdeněk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	344119
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/09:00336360
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	autoprocessing; activator InsP6 inositol hexakisphosphate; CPD cysteine protease domain; MARTX(Vc) (en)
http://linked.open.../riv/klicoveSlovo	CPD cysteine protease domain MARTX(Vc) activator InsP6 inositol hexakisphosphate autoprocessing
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[0E75138F4310]
http://linked.open...i/riv/nazevZdroje	Journal of Biological Chemistry
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	284
http://linked.open...iv/tvurceVysledku	Voburka, Zdeněk Anderson, W. F. Minasov, G. Procházková, K. Satchell, K. J. F. Shuvalova, L. A.
http://linked.open...ain/vavai/riv/wos	000269969600037
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	0021-9258
number of pages	12 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Structural and molecular mechanism for autoprocessing of MARTX toxin of Vibrio cholerae at multiple sites Structural and molecular mechanism for autoprocessing of MARTX toxin of Vibrio cholerae at multiple sites Structural and molecular mechanism for autoprocessing of MARTX toxin of Vibrio cholerae at multiple sites Structural and molecular mechanism for autoprocessing of MARTX toxin of Vibrio cholerae at multiple sites

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