About: Enhanced expressions of mRNA for neuropeptide Y and interleukin 1 beta in hypothalamic arcuate nuclei during adjuvant arthritis-induced anorexia in Lewis rats     Goto   Sponge   NotDistinct   Permalink

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  • Food intake is activated by hypothalamic orexigenic neuropeptide Y (NPY) controlled by leptin and ghrelin. Rat adjuvant arthritis (AA), and also human rheumatoid arthritis, is associated with cachexia. In our study, we evaluated NPY expression in hypothalamic arcuate nucleus (nARC) under AA-induced changes in leptin, ghrelin and adiponectin. Anorexia is centrally induced by IL-1β whose expression in the nARC was studied as well. In AA rats, decreased appetite, body mass, and epididymal fat positively correlated with reduced circulating and epididymal fat leptin and adiponectin. Plasma ghrelin was increased. In nARC, mRNA for leptin and ghrelin receptors, NPY, and IL-1beta were over-expressed in AA rats. However, circulating and spleen IL-1beta was unaltered in AA rats. During AA, despite of over-expression of orexigenic NPY in nARC, activated expression of IL-1beta in nARC kept AA-induced anorexia in progress. Lowered adiponectin might contribute to this anorexia.
  • Food intake is activated by hypothalamic orexigenic neuropeptide Y (NPY) controlled by leptin and ghrelin. Rat adjuvant arthritis (AA), and also human rheumatoid arthritis, is associated with cachexia. In our study, we evaluated NPY expression in hypothalamic arcuate nucleus (nARC) under AA-induced changes in leptin, ghrelin and adiponectin. Anorexia is centrally induced by IL-1β whose expression in the nARC was studied as well. In AA rats, decreased appetite, body mass, and epididymal fat positively correlated with reduced circulating and epididymal fat leptin and adiponectin. Plasma ghrelin was increased. In nARC, mRNA for leptin and ghrelin receptors, NPY, and IL-1beta were over-expressed in AA rats. However, circulating and spleen IL-1beta was unaltered in AA rats. During AA, despite of over-expression of orexigenic NPY in nARC, activated expression of IL-1beta in nARC kept AA-induced anorexia in progress. Lowered adiponectin might contribute to this anorexia. (en)
Title
  • Enhanced expressions of mRNA for neuropeptide Y and interleukin 1 beta in hypothalamic arcuate nuclei during adjuvant arthritis-induced anorexia in Lewis rats
  • Enhanced expressions of mRNA for neuropeptide Y and interleukin 1 beta in hypothalamic arcuate nuclei during adjuvant arthritis-induced anorexia in Lewis rats (en)
skos:prefLabel
  • Enhanced expressions of mRNA for neuropeptide Y and interleukin 1 beta in hypothalamic arcuate nuclei during adjuvant arthritis-induced anorexia in Lewis rats
  • Enhanced expressions of mRNA for neuropeptide Y and interleukin 1 beta in hypothalamic arcuate nuclei during adjuvant arthritis-induced anorexia in Lewis rats (en)
skos:notation
  • RIV/61388963:_____/09:00330845!RIV10-AV0-61388963
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA305/06/0427), Z(AV0Z40550506), Z(MSM0021620816)
http://linked.open...iv/cisloPeriodika
  • 6
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 313278
http://linked.open...ai/riv/idVysledku
  • RIV/61388963:_____/09:00330845
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • adjuvant arthritis; anorexia; leptin; adiponectin (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV
  • [6262DBC6AC7F]
http://linked.open...i/riv/nazevZdroje
  • Neuroimmunomodulation
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 16
http://linked.open...iv/tvurceVysledku
  • Železná, Blanka
  • Kiss, A.
  • Haluzík, M.
  • Lacinová, Z.
  • Jurcovicová, J.
  • Skurlová, M.
  • Stofková, A.
http://linked.open...ain/vavai/riv/wos
  • 000270364500002
http://linked.open...n/vavai/riv/zamer
issn
  • 1021-7401
number of pages
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