About: Design and synthesis of bombykol analogues for probing pheromone-binding protein

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Fluorované a thioanalogy bombykolu (samičího sexuálního feromonu bource morušového) byly navrženy na základě ab inicio výpočtů. Tyto analogy byly syntetizovány strategií hydroborace a Sonogashirova couplingu s (5E,7Z)-undekadien-1-olem jakožto běžným meziproduktem. Byl vyvinut test na měření vazebné síly komplexace feromonu či analogu s vazebným proteinem. Naměřené disociační konstanty bombykolu a analogu 4 byly 2.1x106 M a 2.4x106 M. (cs) Fluorinated and thioanalogues of Bombyx mori female sex pheromones (bombykol) were designed according to the ab initio calculations. These analogues were synthesized using hydroboration and Sonogashira coupling strategy via (5E,7Z)-undecadien-1-ol as a common intermediate. A new binding assay based on nanoLC-linear ion trap ESI-MS for quantifying complexation of the B. mori pheromone-binding protein (BmPBP) with native and prepared analogues was developed. The dissociation constant (KD) of bombykol and analogue 4 was determined to be 2.1x106 M and 2.4x106 M, respectively. Fluorinated and thioanalogues of Bombyx mori female sex pheromones (bombykol) were designed according to the ab initio calculations. These analogues were synthesized using hydroboration and Sonogashira coupling strategy via (5E,7Z)-undecadien-1-ol as a common intermediate. A new binding assay based on nanoLC-linear ion trap ESI-MS for quantifying complexation of the B. mori pheromone-binding protein (BmPBP) with native and prepared analogues was developed. The dissociation constant (KD) of bombykol and analogue 4 was determined to be 2.1x106 M and 2.4x106 M, respectively. (en)
Title	Design and synthesis of bombykol analogues for probing pheromone-binding protein–ligand interactions Návrh a syntéza analogů bombykolu pro studium interakcí ligandu s proteinem vázajícím feromon (PBP) (cs) Design and synthesis of bombykol analogues for probing pheromone-binding protein–ligand interactions (en)
skos:prefLabel	Design and synthesis of bombykol analogues for probing pheromone-binding protein–ligand interactions Návrh a syntéza analogů bombykolu pro studium interakcí ligandu s proteinem vázajícím feromon (PBP) (cs) Design and synthesis of bombykol analogues for probing pheromone-binding protein–ligand interactions (en)
skos:notation	RIV/61388963:_____/09:00322756!RIV09-AV0-61388963
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Klusák, Vojtěch Svatoš, Aleš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	309652
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/09:00322756
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	bombykol; pheromone; binding protein; nanoLC (en)
http://linked.open.../riv/klicoveSlovo	bombykol nanoLC binding protein pheromone
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[DB7ABE12D693]
http://linked.open...i/riv/nazevZdroje	Tetrahedron
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	65
http://linked.open...iv/tvurceVysledku	Klusák, Vojtěch Svatoš, Aleš Muck, A. Doubský, J. Mansurova, M. Nešněrová, P.
http://linked.open...ain/vavai/riv/wos	000263218500015
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	0040-4020
number of pages	8 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Design and synthesis of bombykol analogues for probing pheromone-binding protein–ligand interactions Design and synthesis of bombykol analogues for probing pheromone-binding protein–ligand interactions Design and synthesis of bombykol analogues for probing pheromone-binding protein–ligand interactions Design and synthesis of bombykol analogues for probing pheromone-binding protein–ligand interactions

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