About: Purine bases and nucleosides bearing functionalized C-subtituents in position 6. Synthesis and biological activities

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Purinové báze a nukleosidy nesoucí různé funkcionalizované C-substituenty byly připraveny pomocí cross-coupling rekcí 6-halopurinů s chráněnými funkcionalizovanými organokovy nebo pomocí konjugované nukleofilní adice na 6-vinyl- nebo 6-ethynylpuriny. Další typy substituentů byly připraveny dalšími transformacemi funkčních skupin z 6-(mesyloxymethyl)purinů. Systematické tetování biologické aktivity odhalilo několik nových typů purinových nukleosidů s cytostatickou aktivitou a aktivitou proti HCV. (cs) Purine bases and nucleosides bearing diverse functionalized C-substituents have been prepared either via cross-coupling reactions of 6-halopurines with protected functionalized organometallic reagents or via conjugate additions of nucleophiles to 6-vinyl- or 6-ethynylpurines. Other types of substituents have been prepared by further functional group transformations of 6-(mesyloxymethyl)purines. Systematic biological activity screening revealed several new types of cytostatic and anti-HCV purine nucleosides. Purine bases and nucleosides bearing diverse functionalized C-substituents have been prepared either via cross-coupling reactions of 6-halopurines with protected functionalized organometallic reagents or via conjugate additions of nucleophiles to 6-vinyl- or 6-ethynylpurines. Other types of substituents have been prepared by further functional group transformations of 6-(mesyloxymethyl)purines. Systematic biological activity screening revealed several new types of cytostatic and anti-HCV purine nucleosides. (en)
Title	Purine bases and nucleosides bearing functionalized C-subtituents in position 6. Synthesis and biological activities Purinové báze a nukleosidy nesoucí funkcionalizované C-substituenty v pozici 6. Syntéza a biologická aktivita (cs) Purine bases and nucleosides bearing functionalized C-subtituents in position 6. Synthesis and biological activities (en)
skos:prefLabel	Purine bases and nucleosides bearing functionalized C-subtituents in position 6. Synthesis and biological activities Purinové báze a nukleosidy nesoucí funkcionalizované C-substituenty v pozici 6. Syntéza a biologická aktivita (cs) Purine bases and nucleosides bearing functionalized C-subtituents in position 6. Synthesis and biological activities (en)
skos:notation	RIV/61388963:_____/08:00309893!RIV09-AV0-61388963
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0508), P(1QS400550501), Z(AV0Z40550506)
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Hasník, Zbyněk Kuchař, Martin Hocek, Michal Šilhár, Peter Bambuch, Vítězslav
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	391088
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/08:00309893
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	purines; nucleosides; cross-coupling; conjugate addition (en)
http://linked.open.../riv/klicoveSlovo	conjugate addition cross-coupling nucleosides purines
http://linked.open...ontrolniKodProRIV	[B56BFC1A2F4C]
http://linked.open...v/mistoKonaniAkce	Český Krumlov
http://linked.open...i/riv/mistoVydani	Praha
http://linked.open...i/riv/nazevZdroje	Chemistry of Nucleic Acid Components
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	New Antivirals and Antineoplastics Novel antivirals and antineoplastics
http://linked.open...UplatneniVysledku	2008
http://linked.open...iv/tvurceVysledku	Hocek, Michal Kuchař, Martin Hasník, Zbyněk Bambuch, Vítězslav Šilhár, Peter
http://linked.open...vavai/riv/typAkce	EUR - Evropská
http://linked.open...ain/vavai/riv/wos	000257885700024
http://linked.open.../riv/zahajeniAkce	2008-06-08 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
number of pages	4 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Institute of Organic Chemistry and Biochemistry ASCR
https://schema.org/isbn	978-80-86241-29-6
is http://linked.open...avai/riv/vysledek of	Purine bases and nucleosides bearing functionalized C-subtituents in position 6. Synthesis and biological activities Purine bases and nucleosides bearing functionalized C-subtituents in position 6. Synthesis and biological activities Purine bases and nucleosides bearing functionalized C-subtituents in position 6. Synthesis and biological activities Purine bases and nucleosides bearing functionalized C-subtituents in position 6. Synthesis and biological activities

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