About: Cathepsin D propeptide: Mechanism and Regulation of its interaction with the catalytic core

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Propeptid blokuje aktivní místo inaktivního zymogenu katepsinu D a je vyštěpován během zrání. Testovali jsme sadu peptidových fragmentů odvozených od propeptidu a v kinetickém aktivitním testu se zralým katepsinem D jsme určili jejich inhibiční potenciál a mod inhibice. Fragment odvozený od N-konce propeptidu vykazoval největší inhibici. Zkoumali jsme vliv sulfatovaných glykosaminoglykanů a peptidových mutací. (cs) The propeptide blocks the active site of inactive zymogen of cathepsin D and is cleaved off during maturation. We tested set of peptidic fragments derived from the propeptide and evaluated their inhibitory potency and mode of inhibition against mature cathepsin D using kinetic activity assay. Fragment derived from the propeptide N-terminus displayed major inhibition. We investigated influence of sulfated glycosaminoglycans and propeptide mutations. The propeptide blocks the active site of inactive zymogen of cathepsin D and is cleaved off during maturation. We tested set of peptidic fragments derived from the propeptide and evaluated their inhibitory potency and mode of inhibition against mature cathepsin D using kinetic activity assay. Fragment derived from the propeptide N-terminus displayed major inhibition. We investigated influence of sulfated glycosaminoglycans and propeptide mutations. (en)
Title	Cathepsin D propeptide: Mechanism and Regulation of its interaction with the catalytic core Propeptid katepsinu D: mechanismus a regulace jakointerakce s katalytickým jádrem (cs) Cathepsin D propeptide: Mechanism and Regulation of its interaction with the catalytic core (en)
skos:prefLabel	Cathepsin D propeptide: Mechanism and Regulation of its interaction with the catalytic core Propeptid katepsinu D: mechanismus a regulace jakointerakce s katalytickým jádrem (cs) Cathepsin D propeptide: Mechanism and Regulation of its interaction with the catalytic core (en)
skos:notation	RIV/61388963:_____/06:00053658!RIV07-AV0-61388963
http://linked.open.../vavai/riv/strany	15474;15482
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1P04OCB20.002), P(IAA4055303), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	51
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Vondrášek, Jiří Mareš, Michael Máša, Martin Horn, Martin Marešová, Lucie Ježek, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	467872
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/06:00053658
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cathepsin D; propeptide; inhibition (en)
http://linked.open.../riv/klicoveSlovo	propeptide cathepsin D inhibition
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[EC09E2A41460]
http://linked.open...i/riv/nazevZdroje	Biochemistry
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular mechanism of function of proteases in breast cancer Modulation of enzymatic activity in cathepsins
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	45
http://linked.open...iv/tvurceVysledku	Horn, Martin Ježek, Jan Mareš, Michael Máša, Martin Vondrášek, Jiří Marešová, Lucie
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	0006-2960
number of pages	9 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Cathepsin D propeptide: Mechanism and Regulation of its interaction with the catalytic core Cathepsin D propeptide: Mechanism and Regulation of its interaction with the catalytic core

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