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Description
  • Byla vyřešena 3-D struktura enzymu GCPII rentgenovou difrakcí. Struktura vysvětluje, jak se na enzymu váže substrát a inhibitory. (cs)
  • The three-dimensional structures presented here reveal an induced-fit substrate-binding mode of this key enzyme and provide essential information for the design of GCPII inhibitors useful in the treatment of neuronal diseases and prostate cancer.
  • The three-dimensional structures presented here reveal an induced-fit substrate-binding mode of this key enzyme and provide essential information for the design of GCPII inhibitors useful in the treatment of neuronal diseases and prostate cancer. (en)
Title
  • Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer
  • Struktura GCP II, léčebného cíle při neuronálním poškození a nádorech prostaty (cs)
  • Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer (en)
skos:prefLabel
  • Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer
  • Struktura GCP II, léčebného cíle při neuronálním poškození a nádorech prostaty (cs)
  • Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer (en)
skos:notation
  • RIV/61388963:_____/06:00044735!RIV07-AV0-61388963
http://linked.open.../vavai/riv/strany
  • 1375;1384
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1M0508), P(GA301/03/0784), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika
  • 6
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 501990
http://linked.open...ai/riv/idVysledku
  • RIV/61388963:_____/06:00044735
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • NAALADase; neurodegenerative disease; peptidase; prostate cancer (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [D432388C1995]
http://linked.open...i/riv/nazevZdroje
  • EMBO Journal
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 25
http://linked.open...iv/tvurceVysledku
  • Konvalinka, Jan
  • Li, W.
  • Bařinka, Cyril
  • Slusher, B.
  • Mesters, J. R.
  • Tsukamoto, T.
  • Majer, P.
  • Hilgenfeld, R.
http://linked.open...n/vavai/riv/zamer
issn
  • 0261-4189
number of pages
is http://linked.open...avai/riv/vysledek of
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