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Description
  • A new type of acyclic nucleoside phosphonates (ANP) is derived from 2,4-diamino-6-hydroxypyrimidine. These 6-[2-(phosphonomethoxy)ethoxy]pyrimidine derivatives significantly inhibit replication of retroviruses and herpesviruses in cell cultures. This novel subclass of pyrimidine ANPs can be considered as analogues of 2,6-diaminopurine with an open imidazole ring in the purine moiety.
  • A new type of acyclic nucleoside phosphonates (ANP) is derived from 2,4-diamino-6-hydroxypyrimidine. These 6-[2-(phosphonomethoxy)ethoxy]pyrimidine derivatives significantly inhibit replication of retroviruses and herpesviruses in cell cultures. This novel subclass of pyrimidine ANPs can be considered as analogues of 2,6-diaminopurine with an open imidazole ring in the purine moiety. (en)
  • Nový typ acyklických nukleosid fosfonátů (ANP) je odvozen od 2,4-diamino-6-hydroxypyrimidinu. Tyto deriváty 6-[2-(fosfonomethoxy)ethoxy]pyrimidinu inhibují replikaci retrovirů a herpesvirů in vitro. Tyto látky jsou považovány za analogy 2,6-diaminopurinu s otevřeným imidazolovým jádrem. (cs)
Title
  • Synthesis and properties of novel types of chiral open-ring acyclic nucleoside phosphonates
  • Syntéza a vlastnosti chirálních acyklických nukleosid fosfonátů s otevřeným kruhem (cs)
  • Synthesis and properties of novel types of chiral open-ring acyclic nucleoside phosphonates (en)
skos:prefLabel
  • Synthesis and properties of novel types of chiral open-ring acyclic nucleoside phosphonates
  • Syntéza a vlastnosti chirálních acyklických nukleosid fosfonátů s otevřeným kruhem (cs)
  • Synthesis and properties of novel types of chiral open-ring acyclic nucleoside phosphonates (en)
skos:notation
  • RIV/61388963:_____/05:00022000!RIV06-AV0-61388963
http://linked.open.../vavai/riv/strany
  • A31
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...dnocenehoVysledku
  • 545722
http://linked.open...ai/riv/idVysledku
  • RIV/61388963:_____/05:00022000
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  • acyclic nucleoside phosphonate; pyrimidine; antiviral activity (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [CD9122D2061E]
http://linked.open...i/riv/nazevZdroje
  • Antiviral Research
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 65
http://linked.open...iv/tvurceVysledku
  • Holý, Antonín
  • Doláková, Petra
http://linked.open...n/vavai/riv/zamer
issn
  • 0166-3542
number of pages
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