About: Formation of arenicin-1 microdomains in bilayers and their specific lipid interaction revealed by Z-scan FCS

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Z-scan fluorescence correlation spectroscopy (FCS) is employed to characterize the interaction between arenicin-1 and supported lipid bilayers (SLBs) of different compositions. Lipid analogue C8-BODIPY 500/510C5-HPC and ATTO 465 labelled arenicin-1 are used to detect changes in lipid and peptide diffusion upon addition of unlabelled arenicin-1 to SLBs. Arenicin-1 decreases lipid mobility in negatively charged SLBs. According to diffusion law analysis, microdomains of significantly lower lipid mobility are formed. The analysis of peptide FCS data confirms the presence of microdomains for anionic SLBs. No indications of microdomain formation are detected in SLBs composed purely of zwitterionic lipids. Additionally, our FCS results imply that arenicin-1 exists in the form of oligomers and/or aggregates when interacting with membranes of both compositions. Z-scan fluorescence correlation spectroscopy (FCS) is employed to characterize the interaction between arenicin-1 and supported lipid bilayers (SLBs) of different compositions. Lipid analogue C8-BODIPY 500/510C5-HPC and ATTO 465 labelled arenicin-1 are used to detect changes in lipid and peptide diffusion upon addition of unlabelled arenicin-1 to SLBs. Arenicin-1 decreases lipid mobility in negatively charged SLBs. According to diffusion law analysis, microdomains of significantly lower lipid mobility are formed. The analysis of peptide FCS data confirms the presence of microdomains for anionic SLBs. No indications of microdomain formation are detected in SLBs composed purely of zwitterionic lipids. Additionally, our FCS results imply that arenicin-1 exists in the form of oligomers and/or aggregates when interacting with membranes of both compositions. (en)
Title	Formation of arenicin-1 microdomains in bilayers and their specific lipid interaction revealed by Z-scan FCS Formation of arenicin-1 microdomains in bilayers and their specific lipid interaction revealed by Z-scan FCS (en)
skos:prefLabel	Formation of arenicin-1 microdomains in bilayers and their specific lipid interaction revealed by Z-scan FCS Formation of arenicin-1 microdomains in bilayers and their specific lipid interaction revealed by Z-scan FCS (en)
skos:notation	RIV/61388955:_____/11:00358473!RIV12-GA0-61388955
http://linked.open...avai/predkladatel	Ústav fyzikální chemie J. Heyrovského AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GAP208/10/0376), P(GAP208/10/1090), P(LC06063), Z(AV0Z40400503)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Hof, Martin Macháň, Radek Sýkora, Jan Charnavets, Tatsiana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav fyzikální chemie J. Heyrovského AV ČR, v.v.i.
http://linked.open...dnocenehoVysledku	200148
http://linked.open...ai/riv/idVysledku	RIV/61388955:_____/11:00358473
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	arenicin-1; supported lipid bilayers; antibacterial peptide (en)
http://linked.open.../riv/klicoveSlovo	antibacterial peptide arenicin-1 supported lipid bilayers
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[72D13B3A03EB]
http://linked.open...i/riv/nazevZdroje	Analytical and Bioanalytical Chemistry
http://linked.open...in/vavai/riv/obor	CF
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Interaction of antibacterial peptides with the model membranes and possibility of the prediction of their biological activity Flurescence microscopy in biological and medical research Development of New Fluorescence Methods for the Characterization of Pores Formed by Antimicrobial Peptides
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	399
http://linked.open...iv/tvurceVysledku	Hof, Martin Sýkora, Jan Charnavets, Tatsiana Macháň, Radek Ovchinnikova, T. V. Zhmak, M. N.
http://linked.open...ain/vavai/riv/wos	000288398700025
http://linked.open...n/vavai/riv/zamer	Struktura, reaktivita a dynamika molekulárních a biomolekulárních systémů: teorie, experiment, aplikace
issn	1618-2642
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s00216-011-4694-z
is http://linked.open...avai/riv/vysledek of	Formation of arenicin-1 microdomains in bilayers and their specific lipid interaction revealed by Z-scan FCS Formation of arenicin-1 microdomains in bilayers and their specific lipid interaction revealed by Z-scan FCS

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