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| Description
| - Asbestosis and pleural plaques exhibit unpredictable but progressive development, and there are no markers routinely available to measure their prognosis. Asbestos exposure induces the generation of reactive oxygen species, and 8-isoprostane is involved in experimental asbestosrelated lung toxicity. This oxidative stress marker was measured in exhaled breath condensate (EBC) in 92 former asbestos workers with mean age 68.8 1.7 yr and mean duration of asbestos exposure 24.1 2.0 yr. The control group had 46 subjects with mean age 65.2 3.3 yr. The mean level of 8-isoprostane, analyzed by liquid chromatography --:-electrospray ionization- mass spectrometry, was higher in asbestos-exposed subjects (69.5 6.6 pg/ml,p=O.OOOl) compared with the control group, where the concentration was 47.0 7.8 pg/ml. The results presented support the hypothesis that oxidative stress due to asbestos is the main cause of increased 8-isoprostane in EBC
- Asbestosis and pleural plaques exhibit unpredictable but progressive development, and there are no markers routinely available to measure their prognosis. Asbestos exposure induces the generation of reactive oxygen species, and 8-isoprostane is involved in experimental asbestosrelated lung toxicity. This oxidative stress marker was measured in exhaled breath condensate (EBC) in 92 former asbestos workers with mean age 68.8 1.7 yr and mean duration of asbestos exposure 24.1 2.0 yr. The control group had 46 subjects with mean age 65.2 3.3 yr. The mean level of 8-isoprostane, analyzed by liquid chromatography --:-electrospray ionization- mass spectrometry, was higher in asbestos-exposed subjects (69.5 6.6 pg/ml,p=O.OOOl) compared with the control group, where the concentration was 47.0 7.8 pg/ml. The results presented support the hypothesis that oxidative stress due to asbestos is the main cause of increased 8-isoprostane in EBC (en)
- Azbestóza a pleurální plaky mají tendenci se nepředvídatelně, ale neustále vyvíjet a neexistuje rutinní metoda pro hodnocení jejich prognózy. Expozice azbestu vede ke vzniku reaktivních molekul kyslíku a 8-isoprostan je spoluodpovědný za toxicitu vůči plícím. Tento marker oxidativního stresu byl měřen v kondenzátu vydechovaného vzduchu (KVV) u 92 dvou pracovníků, vystavených působení azbestu, jejichž věk byl v průměru 8,8 1,7 let a průměrná doba trvání expozice azbestem byla 24,1 2,0 let. Kontrolní skupina zahrnovala 46 osob s průměrným věkem 65,2 3,3 let. Průměrná hladina 8-isoprostanu, analyzovaného pomocí kapalinové chromatografie-hmotnostní spektrometrie, byla u osob vystavených působení azbestu vyšší (69,5 6.6 pg/ml,p=0,0001) v porovnání s kontrolami, jejichž hladina byla 47,0 7,8 pg/ml. Tyto výsledky podporují hypotézu, že oxidativní stres v důsledku expozice azbestem je hlavní příčinou vyšší hladiny 8-isoprostanu v KVV (cs)
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| Title
| - Increased 8-isoprostane, a marker of oxidative stress in exhaled breath condensate in subjects with asbestos exposure
- Increased 8-isoprostane, a marker of oxidative stress in exhaled breath condensate in subjects with asbestos exposure (en)
- Zvýšená hladina 8-isoprostanu, markeru oxidativního stresu v kondenzátu vydechovaného vzduchu u subjektů vystavených expozici asbestem (cs)
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| skos:prefLabel
| - Increased 8-isoprostane, a marker of oxidative stress in exhaled breath condensate in subjects with asbestos exposure
- Increased 8-isoprostane, a marker of oxidative stress in exhaled breath condensate in subjects with asbestos exposure (en)
- Zvýšená hladina 8-isoprostanu, markeru oxidativního stresu v kondenzátu vydechovaného vzduchu u subjektů vystavených expozici asbestem (cs)
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| skos:notation
| - RIV/61388955:_____/08:00320739!RIV09-MZ0-61388955
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(NR9338), Z(AV0Z40400503), Z(AV0Z50200510), Z(MSM6046137301)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61388955:_____/08:00320739
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - asbestos; asbestosis; pleural hyalinosis (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Kačer, P.
- Kuzma, Marek
- Navrátil, Tomáš
- Fenclová, Z.
- Pelclová, D.
- Lebedová, J.
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| is http://linked.open...avai/riv/vysledek
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