About: Cobalt bis(dicarbollide) derivatives: Solubilization and self-assembly suppression

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cobalt bis(dicarbollide) derivatives are promising therapeutic agents however their utilization is complicated due to their low solubility and self-assembling in water. Earlier we have shown that their solubility can be increased by using of suitable biocompatible excipients - carriers of pharmaceutically active compounds. Expected mechanism of solubilization was disassembling of self-assemblies and complexation of unimers. Newly our results of time-dependent light scattering study correct this presumption. Poor solubility of all derivatives can be easily improved by using various excipients, however only heptakis(2,6-di-O-methyl)-beta-cyclodextrin displays ability to disassemble self-assemblies of all derivatives and suppress their self-assembling. Surprisingly, the other excipients participate on formation of mixed assemblies of derivative/excipient complex or cover assemblies to make them more soluble without decreasing their size. Cobalt bis(dicarbollide) derivatives are promising therapeutic agents however their utilization is complicated due to their low solubility and self-assembling in water. Earlier we have shown that their solubility can be increased by using of suitable biocompatible excipients - carriers of pharmaceutically active compounds. Expected mechanism of solubilization was disassembling of self-assemblies and complexation of unimers. Newly our results of time-dependent light scattering study correct this presumption. Poor solubility of all derivatives can be easily improved by using various excipients, however only heptakis(2,6-di-O-methyl)-beta-cyclodextrin displays ability to disassemble self-assemblies of all derivatives and suppress their self-assembling. Surprisingly, the other excipients participate on formation of mixed assemblies of derivative/excipient complex or cover assemblies to make them more soluble without decreasing their size. (en)
Title	Cobalt bis(dicarbollide) derivatives: Solubilization and self-assembly suppression Cobalt bis(dicarbollide) derivatives: Solubilization and self-assembly suppression (en)
skos:prefLabel	Cobalt bis(dicarbollide) derivatives: Solubilization and self-assembly suppression Cobalt bis(dicarbollide) derivatives: Solubilization and self-assembly suppression (en)
skos:notation	RIV/60461373:22340/11:43892252!RIV12-MSM-22340___
http://linked.open...avai/predkladatel	Fakulta chemicko-inženýrská
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/09/1311), P(KAN200100801), P(LC512), Z(MSM0021620857)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Kaplánek, Robert Král, Vladimír Jakubek, Milan Rak, Jakub
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemicko-inženýrská
http://linked.open...dnocenehoVysledku	190764
http://linked.open...ai/riv/idVysledku	RIV/60461373:22340/11:43892252
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Self-assemblies; Disassembling; Solubilization; Excipients; Cobalt bis(dicarbollide) derivatives (en)
http://linked.open.../riv/klicoveSlovo	Cobalt bis(dicarbollide) derivatives Disassembling Excipients Self-assemblies Solubilization
http://linked.open...odStatuVydavatele	FR - Francouzská republika
http://linked.open...ontrolniKodProRIV	[98C42AE5BFD5]
http://linked.open...i/riv/nazevZdroje	European Journal of Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Synthetic probes for recognition of tumor markers:applications for cell directed apoptosis and targeted photodynamic therapy Bioactive Biocompatible Surfaces and Novel Nanostructured Composites for Applications to Medicine and Drug Delivery Center for biomolecules and complex molecular systems
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	46
http://linked.open...iv/tvurceVysledku	Jakubek, Milan Kaplánek, Robert Král, Vladimír Matějíček, Pavel Rak, Jakub
http://linked.open...ain/vavai/riv/wos	000289048400017
http://linked.open...n/vavai/riv/zamer	Nové molekulární systémy pro pokročilé aplikace prospěšné pro zdraví a šetrné k životnímu prostředí
issn	0223-5234
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.ejmech.2011.01.032
http://localhost/t...ganizacniJednotka	22340
is http://linked.open...avai/riv/vysledek of	Cobalt bis(dicarbollide) derivatives: Solubilization and self-assembly suppression Cobalt bis(dicarbollide) derivatives: Solubilization and self-assembly suppression

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