About: Chitosan derivatives as bile acid and cholesterol sorbents

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	This work is devoted to preparation of hydrophobically modified chitosans and evaluation of their sorption properties. N,N,(N)-Di(tri)methylchitosan (MC1) was prepared by the reaction of chitosan with methyl iodide; N,O-palmitoyl-chitosan (MC2) and N,N,(N)-di(tri)methyl-N,O-palmitoyl-chitosan (MC3) were prepared by the reaction of chitosan and MC1 with palmitoyl chloride, respectively. These modified chitosans were characterized by organic elemental analysis, FTIR, NMR, and DSC. The degrees of substitution were calculated from the N/C ratio and from the areas of NMR signals. The in vitro sorption of cholate and cholesterol by chitosan derivatives was studied in comparison with the original chitosan and cholestyramine, an effective synthetic sorbent of bile acids. It was found that MC2 and MC3 are able to bind cholesterol and bile acids, respectively, and thus can be used as cholestyramine supplements to improve cholesterol metabolism. This work is devoted to preparation of hydrophobically modified chitosans and evaluation of their sorption properties. N,N,(N)-Di(tri)methylchitosan (MC1) was prepared by the reaction of chitosan with methyl iodide; N,O-palmitoyl-chitosan (MC2) and N,N,(N)-di(tri)methyl-N,O-palmitoyl-chitosan (MC3) were prepared by the reaction of chitosan and MC1 with palmitoyl chloride, respectively. These modified chitosans were characterized by organic elemental analysis, FTIR, NMR, and DSC. The degrees of substitution were calculated from the N/C ratio and from the areas of NMR signals. The in vitro sorption of cholate and cholesterol by chitosan derivatives was studied in comparison with the original chitosan and cholestyramine, an effective synthetic sorbent of bile acids. It was found that MC2 and MC3 are able to bind cholesterol and bile acids, respectively, and thus can be used as cholestyramine supplements to improve cholesterol metabolism. (en)
Title	Chitosan derivatives as bile acid and cholesterol sorbents Chitosan derivatives as bile acid and cholesterol sorbents (en)
skos:prefLabel	Chitosan derivatives as bile acid and cholesterol sorbents Chitosan derivatives as bile acid and cholesterol sorbents (en)
skos:notation	RIV/60461373:22330/11:43893068!RIV12-MSM-22330___
http://linked.open...avai/predkladatel	Fakulta potravinářské a biochemické technologie
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GAP503/11/2479), Z(MSM6046137305)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Tůma, Jan Čopíková, Jana Synytsya, Andriy
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta potravinářské a biochemické technologie
http://linked.open...dnocenehoVysledku	190232
http://linked.open...ai/riv/idVysledku	RIV/60461373:22330/11:43893068
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	chitosan, hydrophobic modification, cholestyramine, in vitro sorption, cholesterol, bile acids (en)
http://linked.open.../riv/klicoveSlovo	cholesterol bile acids chitosan cholestyramine hydrophobic modification in vitro sorption
http://linked.open...odStatuVydavatele	KR - Korejská republika
http://linked.open...ontrolniKodProRIV	[52410BD6B60C]
http://linked.open...i/riv/nazevZdroje	Journal of Chitin and Chitosan
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Inhibition of intestinal absorption of sterols by hydrophobically modified polysaccharides
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	16
http://linked.open...iv/tvurceVysledku	Dušková, Dagmar Marounek, Milan Synytsya, Andriy Tůma, Jan Čopíková, Jana
http://linked.open...n/vavai/riv/zamer	Teoretické základy potravinářských a biochemických technologií
issn	1229-4160
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	22330
is http://linked.open...avai/riv/vysledek of	Chitosan derivatives as bile acid and cholesterol sorbents Chitosan derivatives as bile acid and cholesterol sorbents

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