About: Inhibition of HIV-1 integrase by modified oligonucleotides derived from U5´ LTR.

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About: Inhibition of HIV-1 integrase by modified oligonucleotides derived from U5´ LTR. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Retroviral integrase integrates viral DNA into the host chromosome by a process that is an attractive target for drug design. In the 3´ processing, two nucleotides are cleaved from 3´ ends of viral DNA yielding a 5´ phosphorylated dimer. The inhibitionsof 3´ processing and strand transfer reactions were studied using 21-mer oligonucleotides containing isopolar, nonisosteric phos- phonate internucleotide and conformationally restricted isopolar, isosteric phosphodiester linkages. Retroviral integrase integrates viral DNA into the host chromosome by a process that is an attractive target for drug design. In the 3´ processing, two nucleotides are cleaved from 3´ ends of viral DNA yielding a 5´ phosphorylated dimer. The inhibitionsof 3´ processing and strand transfer reactions were studied using 21-mer oligonucleotides containing isopolar, nonisosteric phos- phonate internucleotide and conformationally restricted isopolar, isosteric phosphodiester linkages. (en)
Title	Inhibition of HIV-1 integrase by modified oligonucleotides derived from U5´ LTR. Inhibition of HIV-1 integrase by modified oligonucleotides derived from U5´ LTR. (en)
skos:prefLabel	Inhibition of HIV-1 integrase by modified oligonucleotides derived from U5´ LTR. Inhibition of HIV-1 integrase by modified oligonucleotides derived from U5´ LTR. (en)
skos:notation	RIV/60461373:22330/01:00009076!RIV/2004/MSM/223304/N
http://linked.open.../vavai/riv/strany	980;986
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAA4055904), P(LN00A079), P(NL5441), Z(AV0Z4055905)
http://linked.open...iv/cisloPeriodika	268
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Ruml, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta potravinářské a biochemické technologie
http://linked.open...dnocenehoVysledku	683016
http://linked.open...ai/riv/idVysledku	RIV/60461373:22330/01:00009076
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Inhibition, integrase, HIV (en)
http://linked.open.../riv/klicoveSlovo	Inhibition HIV integrase
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[4BCF97CC6116]
http://linked.open...i/riv/nazevZdroje	Europian Journal of Biochemistry
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Integrated Genomics Study of structure, function and inhibition of retroviral integrase and proteinase Novel phosphonate oligonucleotide inhibitors of retroviral integrases
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	Neuveden
http://linked.open...iv/tvurceVysledku	Rosenberg, Ivan Ruml, Tomáš Rejman, Dominik Točík, Zdeněk Liboska, Radek Snášel, Jan
http://linked.open...n/vavai/riv/zamer	Chemical principles of selected biological phenomena in medicine and ecology
issn	0014-2956
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	22330

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