About: Characterization of Mammalian Orthologues of the Drosophila osa Gene: cDNA Cloning, Expression, Chromosomal Localization, and Direct Physical Interaction with Brahma Chromatin-Remodeling Complex. Genomics

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About: Characterization of Mammalian Orthologues of the Drosophila osa Gene: cDNA Cloning, Expression, Chromosomal Localization, and Direct Physical Interaction with Brahma Chromatin-Remodeling Complex. Genomics Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The osa gene of Drosophila melanogaster encodes a nuclear protein that is a component of the Brahma chromatin-remodeling complex. Osa is required for embryonic segmentation, development of the notum and wing margin, and photoreceptor differentiation. In these tissues, osa mutations have effects opposite to those caused by wingless (wg) mutations, suggesting that osa functions as an antagonist of wg signaling. Here we describe the cloning and characterization of mammalian orthologues of osa. Three evolutionarily conserved domains were identified in Osa family members: the N-terminal Bright domain and C-terminally located Osa homology domains 1 and 2. RNase protection analysis indicates a widespread expression of the Osa1 gene during mouse development, in adult tissues, and in cultured cell lines. The Osa1 gene was localized to mouse chromosome 4, within the region syntenic to chromosomal position 1p35-p36 of its human counterpart. We present evidence that the OSA1 product is localized in the nucleus an The osa gene of Drosophila melanogaster encodes a nuclear protein that is a component of the Brahma chromatin-remodeling complex. Osa is required for embryonic segmentation, development of the notum and wing margin, and photoreceptor differentiation. In these tissues, osa mutations have effects opposite to those caused by wingless (wg) mutations, suggesting that osa functions as an antagonist of wg signaling. Here we describe the cloning and characterization of mammalian orthologues of osa. Three evolutionarily conserved domains were identified in Osa family members: the N-terminal Bright domain and C-terminally located Osa homology domains 1 and 2. RNase protection analysis indicates a widespread expression of the Osa1 gene during mouse development, in adult tissues, and in cultured cell lines. The Osa1 gene was localized to mouse chromosome 4, within the region syntenic to chromosomal position 1p35-p36 of its human counterpart. We present evidence that the OSA1 product is localized in the nucleus an (en)
Title	Characterization of Mammalian Orthologues of the Drosophila osa Gene: cDNA Cloning, Expression, Chromosomal Localization, and Direct Physical Interaction with Brahma Chromatin-Remodeling Complex. Genomics Characterization of Mammalian Orthologues of the Drosophila osa Gene: cDNA Cloning, Expression, Chromosomal Localization, and Direct Physical Interaction with Brahma Chromatin-Remodeling Complex. Genomics (en)
skos:prefLabel	Characterization of Mammalian Orthologues of the Drosophila osa Gene: cDNA Cloning, Expression, Chromosomal Localization, and Direct Physical Interaction with Brahma Chromatin-Remodeling Complex. Genomics Characterization of Mammalian Orthologues of the Drosophila osa Gene: cDNA Cloning, Expression, Chromosomal Localization, and Direct Physical Interaction with Brahma Chromatin-Remodeling Complex. Genomics (en)
skos:notation	RIV/60461373:22330/01:00004298!RIV/2004/MSM/223304/N
http://linked.open.../vavai/riv/strany	140;148
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(LN00A079)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Vlček, Čestmír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta potravinářské a biochemické technologie
http://linked.open...dnocenehoVysledku	675388
http://linked.open...ai/riv/idVysledku	RIV/60461373:22330/01:00004298
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	osa gene; Drosophila melanogaster; wg (en)
http://linked.open.../riv/klicoveSlovo	Drosophila melanogaster osa gene wg
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[1548C529A1DB]
http://linked.open...i/riv/nazevZdroje	Genomics
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Integrated Genomics
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	73
http://linked.open...iv/tvurceVysledku	Kozmik, Zbyněk Králová, Jarmila Pačes, Jan Vlček, Čestmír Machoň, Ondřej Krešlová, Jana
issn	0888-7543
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	22330

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