About: Search for urinary DNA adducts derived from p-benzoquinone, an electrophilic metabolite of benzene

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Although the adducts of various chemical carcinogens with DNA have been studied extensively, little is known about their excretion in the urine, which can be used for a non-invasive assessment of the overall DNA adduct formation in the body. For example, no DNA adducts arising from exposure to benzene, a ubiquitous industrial and environmental genotoxic carcinogen, have been found in the urine as yet. Here we wished to detect in mouse urine the DNA adducts derived from the benzene metabolite p-benzoquinone (BQ), which was reported to react with 2´-deoxyadenosine, 2´-deoxyguanosine and 2´-deoxycytidine in double stranded DNA (but not in tumour cells or in vivo) to give cyclic adducts, identified as 9-hydroxy-1,N6-benzeno-2?-deoxyadenosine (DABQ), 7-hydroxy-1,N2-benzeno-2?-deoxyguanosine (DGBQ) and 3-hydroxy-3,N4-benzeno-2?-deoxycytidine (DCBQ), respectively. In our analytical study we developed sensitive LC/MS methods for the determination of DABQ, DGBQ, DCBQ as well as of two deribosylated analogues, Although the adducts of various chemical carcinogens with DNA have been studied extensively, little is known about their excretion in the urine, which can be used for a non-invasive assessment of the overall DNA adduct formation in the body. For example, no DNA adducts arising from exposure to benzene, a ubiquitous industrial and environmental genotoxic carcinogen, have been found in the urine as yet. Here we wished to detect in mouse urine the DNA adducts derived from the benzene metabolite p-benzoquinone (BQ), which was reported to react with 2´-deoxyadenosine, 2´-deoxyguanosine and 2´-deoxycytidine in double stranded DNA (but not in tumour cells or in vivo) to give cyclic adducts, identified as 9-hydroxy-1,N6-benzeno-2?-deoxyadenosine (DABQ), 7-hydroxy-1,N2-benzeno-2?-deoxyguanosine (DGBQ) and 3-hydroxy-3,N4-benzeno-2?-deoxycytidine (DCBQ), respectively. In our analytical study we developed sensitive LC/MS methods for the determination of DABQ, DGBQ, DCBQ as well as of two deribosylated analogues, (en)
Title	Search for urinary DNA adducts derived from p-benzoquinone, an electrophilic metabolite of benzene Search for urinary DNA adducts derived from p-benzoquinone, an electrophilic metabolite of benzene (en)
skos:prefLabel	Search for urinary DNA adducts derived from p-benzoquinone, an electrophilic metabolite of benzene Search for urinary DNA adducts derived from p-benzoquinone, an electrophilic metabolite of benzene (en)
skos:notation	RIV/60461373:22310/10:00023746!RIV11-MSM-22310___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(2B08051)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Linhart, Igor
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemické technologie
http://linked.open...dnocenehoVysledku	286566
http://linked.open...ai/riv/idVysledku	RIV/60461373:22310/10:00023746
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Benzene; p-benzoquinone; DNA adducts (en)
http://linked.open.../riv/klicoveSlovo	DNA adducts Benzene p-benzoquinone
http://linked.open...ontrolniKodProRIV	[92DA51010792]
http://linked.open...v/mistoKonaniAkce	Espoo, Finsko
http://linked.open...i/riv/mistoVydani	Helsinky
http://linked.open...i/riv/nazevZdroje	Programme and Abstracts ISBM 2010
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	New Strategy for Biological Monitoring of Exposure to Mutagens and Carcinogens
http://linked.open...UplatneniVysledku	2010
http://linked.open...iv/tvurceVysledku	Mikeš, Petr Urbanová, Martina Frantík, Emil Linhart, Igor Mráz, J.
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2010-01-01 (xsd:date)
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Finnish Institute of Occupational Health
https://schema.org/isbn	978-952-261-008-9
http://localhost/t...ganizacniJednotka	22310
is http://linked.open...avai/riv/vysledek of	Search for urinary DNA adducts derived from p-benzoquinone, an electrophilic metabolite of benzene Search for urinary DNA adducts derived from p-benzoquinone, an electrophilic metabolite of benzene Search for urinary DNA adducts derived from p-benzoquinone, an electrophilic metabolite of benzene

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