About: New urinary matabolites formed from ring-oxidized metabolic intermediates of styrene

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The urine from mice exposed to styrene vapors (600 and 1200 mg/m3, 6h) was analyzed for ring-oxidized metabolites of styrene. To facilitate the identification of metabolites in urine, following potential metabolites were prepared: 2-, 3-, and 4-vinylphenol (2-, 3- and 4-VP), 4-vinylpyrocatechol, and 2-, 3- and 4-vinylphenylmercapturic acid (2-, 3- and 4-VPMA). For the analysis of vinylphenols beta-glucuronidase-treated urine was extracted and derivatized with acetanhydride/ triethylamine before the injection into GC/MS. Three isomers, 2-, 3- and 4-VP, were found in the exposed urine using authentic standards. Additionally, three novel minor urinary metabolites, arylmercapturic acids 2-, 3- and 4-VPMA, were identified by LC-ESI-MS2 by comparison with authentic standards. Excretion of the most abundant isomer, 4-VPMA, amounted to 535 +/- 47 nmol/kg and 984 +/- 78 nmol/kg, representing approx. 0.047 and 0.043 % of the absorbed dose for the exposure levels of 600 and 1200 mg/m3, respectively. The ratio The urine from mice exposed to styrene vapors (600 and 1200 mg/m3, 6h) was analyzed for ring-oxidized metabolites of styrene. To facilitate the identification of metabolites in urine, following potential metabolites were prepared: 2-, 3-, and 4-vinylphenol (2-, 3- and 4-VP), 4-vinylpyrocatechol, and 2-, 3- and 4-vinylphenylmercapturic acid (2-, 3- and 4-VPMA). For the analysis of vinylphenols beta-glucuronidase-treated urine was extracted and derivatized with acetanhydride/ triethylamine before the injection into GC/MS. Three isomers, 2-, 3- and 4-VP, were found in the exposed urine using authentic standards. Additionally, three novel minor urinary metabolites, arylmercapturic acids 2-, 3- and 4-VPMA, were identified by LC-ESI-MS2 by comparison with authentic standards. Excretion of the most abundant isomer, 4-VPMA, amounted to 535 +/- 47 nmol/kg and 984 +/- 78 nmol/kg, representing approx. 0.047 and 0.043 % of the absorbed dose for the exposure levels of 600 and 1200 mg/m3, respectively. The ratio (en)
Title	New urinary matabolites formed from ring-oxidized metabolic intermediates of styrene New urinary matabolites formed from ring-oxidized metabolic intermediates of styrene (en)
skos:prefLabel	New urinary matabolites formed from ring-oxidized metabolic intermediates of styrene New urinary matabolites formed from ring-oxidized metabolic intermediates of styrene (en)
skos:notation	RIV/60461373:22310/10:00022959!RIV11-MSM-22310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(2B08051), Z(MSM6046137301)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Krouželka, Jan Linhart, Igor
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemické technologie
http://linked.open...dnocenehoVysledku	274801
http://linked.open...ai/riv/idVysledku	RIV/60461373:22310/10:00022959
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Metabolic activation; reactive intermediates; arene oxides; styrene; mercapturic acids (en)
http://linked.open.../riv/klicoveSlovo	reactive intermediates Metabolic activation arene oxides mercapturic acids styrene
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[4D39DA0C2F1F]
http://linked.open...i/riv/nazevZdroje	Chem. Res. Toxicol.
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	New Strategy for Biological Monitoring of Exposure to Mutagens and Carcinogens
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	23
http://linked.open...iv/tvurceVysledku	Linhart, Igor Mráz, Jaroslav Krouželka, Jan Dušková, Šárka Nohová, Hana Scharff, Jan Vodičková, Ľudmila
http://linked.open...ain/vavai/riv/wos	000273618500029
http://linked.open...n/vavai/riv/zamer	Catalytic processes in chemistry and chemical technology
issn	0893-228X
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	22310
is http://linked.open...avai/riv/vysledek of	New urinary matabolites formed from ring-oxidized metabolic intermediates of styrene New urinary matabolites formed from ring-oxidized metabolic intermediates of styrene New urinary matabolites formed from ring-oxidized metabolic intermediates of styrene

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