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rdf:type
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Description
| - 3-(2-Hydroxy-2-phenylethyl)- and 3-(2-hydroxy-1-phenylethyl)adenine, DNA adducts derived from styrene, along with their 9-substituted analogues were prepared by alkylation of 8-bromoadenine with corresponding allyl-protected bromohydrins followed by a new deallylation procedure using tetrakis(triphenylphosphine)palladium catalyzed reductive cleavage by poly(methylhydrosiloxane) in the presence of p-toluenesulphonic acid. This novel procedure proved to be useful for purine derivatives, which were resistant to other deallylation protocols. Structure of positional isomers was assigned using 2D NMR experiments HMBC and HMQC.
- 3-(2-Hydroxy-2-phenylethyl)- and 3-(2-hydroxy-1-phenylethyl)adenine, DNA adducts derived from styrene, along with their 9-substituted analogues were prepared by alkylation of 8-bromoadenine with corresponding allyl-protected bromohydrins followed by a new deallylation procedure using tetrakis(triphenylphosphine)palladium catalyzed reductive cleavage by poly(methylhydrosiloxane) in the presence of p-toluenesulphonic acid. This novel procedure proved to be useful for purine derivatives, which were resistant to other deallylation protocols. Structure of positional isomers was assigned using 2D NMR experiments HMBC and HMQC. (en)
- 3-(1-Fenyl-2-hydroxyethyl)- a 3-(2-fenyl-2-hydroxyethyl)adenin byly připraveny spolu s příslušnými 9-substituovanými adeniny alkylací 8-bromadeninu s následnou debromací a odchráněným. Připravené 3-substituované adeniny jsou pravděpodobnými DNA adukty odvozenými od styrenu a budou použity jako analytické standardy pro vývoj metod biologického monitorování exposice styrenu. (cs)
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Title
| - Synthesis of 3-(2-Hydroxy-1-phenylethyl)- and 3-(2-Hydroxy-2-phenylethyl)adenine, DNA Adducts Derived from Styrene
- Synthesis of 3-(2-Hydroxy-1-phenylethyl)- and 3-(2-Hydroxy-2-phenylethyl)adenine, DNA Adducts Derived from Styrene (en)
- Syntéza 3-(1-fenyl-2-hydroxyethyl)- a 3-(2-fenyl-2-hydroxyethyl)adeninu, DNA aduktů odvozených od styrenu (cs)
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skos:prefLabel
| - Synthesis of 3-(2-Hydroxy-1-phenylethyl)- and 3-(2-Hydroxy-2-phenylethyl)adenine, DNA Adducts Derived from Styrene
- Synthesis of 3-(2-Hydroxy-1-phenylethyl)- and 3-(2-Hydroxy-2-phenylethyl)adenine, DNA Adducts Derived from Styrene (en)
- Syntéza 3-(1-fenyl-2-hydroxyethyl)- a 3-(2-fenyl-2-hydroxyethyl)adeninu, DNA aduktů odvozených od styrenu (cs)
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skos:notation
| - RIV/60461373:22310/08:00020022!RIV09-MSM-22310___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA203/06/0888), P(LC06070), Z(MSM6046137301)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/60461373:22310/08:00020022
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Alkylation of purines; 3-Alykladenines; DNA adducts; styrene (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Journal of Heterocyclic Chemistry
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Linhart, Igor
- Tobrman, Tomáš
- Krouželka, Jan
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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is http://linked.open...avai/riv/vysledek
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