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  • Both, 6-chloro-2-iodo-9-isopropylpurine (1) and 2-chloro-6-iodo-9-benzylpurine (4) undergo selective I/Mg exchange reaction with iPrMgCl at -80°C. The reaction course at 0°C is different. Magnesiation of 1 proceeds with the migration of magnesium to the position 8 of purine nuclei. In the case of 4, substitution of iodine with alkylgroup from Grignard reagent accompanied with Cl/Mg exchange reaction takes place, and 6-alkyl-2-magnesiated purines (9) are formed. Thus prepared Grignard reagents afford the corresponding alcohols by the reaction with aldehydes.
  • Both, 6-chloro-2-iodo-9-isopropylpurine (1) and 2-chloro-6-iodo-9-benzylpurine (4) undergo selective I/Mg exchange reaction with iPrMgCl at -80°C. The reaction course at 0°C is different. Magnesiation of 1 proceeds with the migration of magnesium to the position 8 of purine nuclei. In the case of 4, substitution of iodine with alkylgroup from Grignard reagent accompanied with Cl/Mg exchange reaction takes place, and 6-alkyl-2-magnesiated purines (9) are formed. Thus prepared Grignard reagents afford the corresponding alcohols by the reaction with aldehydes. (en)
  • Oba 6-chlor-2-jod-9-isopropylpurin (1) a 2-chlor-6-jod-9-benzylpurin (4) podléhají selektivní výměnné reakci s i-PrMgCl při -80°C. (cs)
Title
  • Selective magnesiation of chloro-iodopurines: An efficient approach to new purine derivatives.
  • Selektivní magnesiace chlor-jodpurinů: Efektivní přístup k novým purinovým derivátům (cs)
  • Selective magnesiation of chloro-iodopurines: An efficient approach to new purine derivatives. (en)
skos:prefLabel
  • Selective magnesiation of chloro-iodopurines: An efficient approach to new purine derivatives.
  • Selektivní magnesiace chlor-jodpurinů: Efektivní přístup k novým purinovým derivátům (cs)
  • Selective magnesiation of chloro-iodopurines: An efficient approach to new purine derivatives. (en)
skos:notation
  • RIV/60461373:22310/06:00016989!RIV07-GA0-22310___
http://linked.open.../vavai/riv/strany
  • 1291-1294
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA203/03/0035)
http://linked.open...iv/cisloPeriodika
  • 7
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 498789
http://linked.open...ai/riv/idVysledku
  • RIV/60461373:22310/06:00016989
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Magnesiation; Purines; Metallation (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [9ED0098478F1]
http://linked.open...i/riv/nazevZdroje
  • Organic Letters
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 8
http://linked.open...iv/tvurceVysledku
  • Dvořák, Dalimil
  • Tobrman, Tomáš
issn
  • 1523-7060
number of pages
http://localhost/t...ganizacniJednotka
  • 22310
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