About: Mitoxantrone in combination with a DNA-PK inhibitor: Possible therapy of promyelocytic leukaemia resistant forms

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About: Mitoxantrone in combination with a DNA-PK inhibitor: Possible therapy of promyelocytic leukaemia resistant forms Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://fb.cuni.cz/file/5600/FB2011A0029.pdf
Description	The aim of the study was to sensitize cells of human promyelocytic leukaemia HL-60/MX2 (resistant to mitoxantrone and further substances interacting with topoisomerase II - TI II) to the effect of mitoxantrone (MTX). We demonstrated that the main mechanism of the HL-60/MX2 cell atypical multiple drug resistance is not only their altered activity of TI II and reduced levels of TI II α and β. The resistance of the HL-60/MX2 cells to MTX is associated with their increased ability to repair DSB. The HL-60/MX2 cells, compared to HL-60 cells (which are MTX-sensitive), contain large amounts of DNA-PK, which is responsible for the main pathway of the DSB repair, non-homogenous end joining (NHEJ), and they also contain large amounts of further repair proteins Rad50 and Nbs1, which are important in both NHEJ and homologous re-combination. We demonstrated that specific DNA-PK inhibitor NU7026 in HL60/MX2 prevented DSB repair through the NHEJ pathway and essentially abolished the resistance to MTX. The aim of the study was to sensitize cells of human promyelocytic leukaemia HL-60/MX2 (resistant to mitoxantrone and further substances interacting with topoisomerase II - TI II) to the effect of mitoxantrone (MTX). We demonstrated that the main mechanism of the HL-60/MX2 cell atypical multiple drug resistance is not only their altered activity of TI II and reduced levels of TI II α and β. The resistance of the HL-60/MX2 cells to MTX is associated with their increased ability to repair DSB. The HL-60/MX2 cells, compared to HL-60 cells (which are MTX-sensitive), contain large amounts of DNA-PK, which is responsible for the main pathway of the DSB repair, non-homogenous end joining (NHEJ), and they also contain large amounts of further repair proteins Rad50 and Nbs1, which are important in both NHEJ and homologous re-combination. We demonstrated that specific DNA-PK inhibitor NU7026 in HL60/MX2 prevented DSB repair through the NHEJ pathway and essentially abolished the resistance to MTX. (en)
Title	Mitoxantrone in combination with a DNA-PK inhibitor: Possible therapy of promyelocytic leukaemia resistant forms Mitoxantrone in combination with a DNA-PK inhibitor: Possible therapy of promyelocytic leukaemia resistant forms (en)
skos:prefLabel	Mitoxantrone in combination with a DNA-PK inhibitor: Possible therapy of promyelocytic leukaemia resistant forms Mitoxantrone in combination with a DNA-PK inhibitor: Possible therapy of promyelocytic leukaemia resistant forms (en)
skos:notation	RIV/60162694:G44__/11:00002579!RIV12-MO0-G44_____
http://linked.open...avai/riv/aktivita	I Z
http://linked.open...avai/riv/aktivity	I, Z(MO0FVZ0000501)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Vávrová, Jiřina Tichý, Aleš Fabrik, Ivo
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	212717
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/11:00002579
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HL-60/MX2; mitoxantrone; double-strand breaks; multiple drug resistance; DNA-PK; NU7026 inhibitor (en)
http://linked.open.../riv/klicoveSlovo	double-strand breaks DNA-PK HL-60/MX2 NU7026 inhibitor mitoxantrone multiple drug resistance
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[36AEBB39BF98]
http://linked.open...i/riv/nazevZdroje	Folia biologica (Prague)
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	57
http://linked.open...iv/tvurceVysledku	Tichý, Aleš Vávrová, Jiřina Řezáčová, Martina Mikusová, Veronika
http://linked.open...ain/vavai/riv/wos	000297182800004
http://linked.open...n/vavai/riv/zamer	Zdravotnická problematika ZHN
issn	0015-5500
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	G44
is http://linked.open...avai/riv/vysledek of	Mitoxantrone in combination with a DNA-PK inhibitor: Possible therapy of promyelocytic leukaemia resistant forms

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