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Description
  • Secreted proteins and secretion pathways are essential for bacterial life and the pathogenesis of infections opens up possibilities of screening novel drugs for antimicrobial therapy, compounds specifically able to inhibit the secretory pathways of pathogens, target molecules for novel diagnostic approaches and immunoprotective secreted proteins for the construction of subcellular vaccines. In bacteria target molecules for secretion must be exported across the cell envelope and for the process of protein secretion, specific molecular machineries are necessary. The secreted proteins act outside of the bacterial cell, either bound to the bacterial cell surface, or freely in the extracellular milieu (host cell); and they are often implicated in the pathogenesis of infections and are involved in virulence.
  • Secreted proteins and secretion pathways are essential for bacterial life and the pathogenesis of infections opens up possibilities of screening novel drugs for antimicrobial therapy, compounds specifically able to inhibit the secretory pathways of pathogens, target molecules for novel diagnostic approaches and immunoprotective secreted proteins for the construction of subcellular vaccines. In bacteria target molecules for secretion must be exported across the cell envelope and for the process of protein secretion, specific molecular machineries are necessary. The secreted proteins act outside of the bacterial cell, either bound to the bacterial cell surface, or freely in the extracellular milieu (host cell); and they are often implicated in the pathogenesis of infections and are involved in virulence. (en)
Title
  • Analysis of culture filtrate proteins of Francisella tularensis
  • Analysis of culture filtrate proteins of Francisella tularensis (en)
skos:prefLabel
  • Analysis of culture filtrate proteins of Francisella tularensis
  • Analysis of culture filtrate proteins of Francisella tularensis (en)
skos:notation
  • RIV/60162694:G44__/11:00002569!RIV12-MO0-G44_____
http://linked.open...avai/riv/aktivita
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  • Z(MO0FVZ0000501)
http://linked.open...vai/riv/dodaniDat
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  • 185629
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  • RIV/60162694:G44__/11:00002569
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  • mass spectrometry; bacteria; secretome; protein identification (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [210BCAB82F3C]
http://linked.open...i/riv/mistoVydani
  • Weinheim
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  • BSL3 and BSL4 agents
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  • Hernychová, Lenka
  • Hubálek, Martin
  • Konečná, Klára
http://linked.open...n/vavai/riv/zamer
number of pages
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  • Wiley (Weinheim)
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  • 978-3-527-32780-5
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  • G44
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