About: Macrophage-assisted inflammation and pharmacological regulation of the cholinergic anti-inflammatory pathway

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About: Macrophage-assisted inflammation and pharmacological regulation of the cholinergic anti-inflammatory pathway Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.2174/092986711794480140
Description	Macrophages play an important role in the immune system. They also participate in multiple processes including angiogenesis and triggering of inflammation. The present study summarizes pieces of knowledge on the importance of macrophages in disease, especially the inflammation. Special attention is paid to the cholinergic anti-inflammatory pathway (CAP) associated with the nicotinic acetylcholine receptor (nAChR) and the parasympathetic nervous system. The current pharmacological effectiveness in suppressing the inflammation in general and the septic shock in particular, is limited. CAP was discovered recently and it seems to be a suitable target for the development of new drugs. Moreover, available drugs binding to either nAChR or acetylcholinesterase (AChE) are candidates for either an inhibition or enhancement of CAP. Though the current scientific databases do not include all necessary data on the association of CAP with body functions and the research is quite intensive, the objective of the present review is to introduce the current trends and to critically evaluate CAP and macrophage-associated pathways. Macrophages play an important role in the immune system. They also participate in multiple processes including angiogenesis and triggering of inflammation. The present study summarizes pieces of knowledge on the importance of macrophages in disease, especially the inflammation. Special attention is paid to the cholinergic anti-inflammatory pathway (CAP) associated with the nicotinic acetylcholine receptor (nAChR) and the parasympathetic nervous system. The current pharmacological effectiveness in suppressing the inflammation in general and the septic shock in particular, is limited. CAP was discovered recently and it seems to be a suitable target for the development of new drugs. Moreover, available drugs binding to either nAChR or acetylcholinesterase (AChE) are candidates for either an inhibition or enhancement of CAP. Though the current scientific databases do not include all necessary data on the association of CAP with body functions and the research is quite intensive, the objective of the present review is to introduce the current trends and to critically evaluate CAP and macrophage-associated pathways. (en)
Title	Macrophage-assisted inflammation and pharmacological regulation of the cholinergic anti-inflammatory pathway Macrophage-assisted inflammation and pharmacological regulation of the cholinergic anti-inflammatory pathway (en)
skos:prefLabel	Macrophage-assisted inflammation and pharmacological regulation of the cholinergic anti-inflammatory pathway Macrophage-assisted inflammation and pharmacological regulation of the cholinergic anti-inflammatory pathway (en)
skos:notation	RIV/60162694:G44__/11:00002507!RIV12-MO0-G44_____
http://linked.open...avai/riv/aktivita	S V Z
http://linked.open...avai/riv/aktivity	S, V, Z(MO0FVZ0000501)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Šinkorová, Zuzana Fusek, Josef Boštík, Pavel Kuča, Kamil Pohanka, Doc. RNDr. PhD, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	210175
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/11:00002507
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Innate immunity; cell; infection; parasympathetic nervous system; inflammation; tumour necrosis factor; acetylcholine receptor; acetylcholinesterase. (en)
http://linked.open.../riv/klicoveSlovo	Innate immunity acetylcholine receptor acetylcholinesterase. parasympathetic nervous system tumour necrosis factor cell infection inflammation
http://linked.open...odStatuVydavatele	AE - Stát Spojené arabské emiráty
http://linked.open...ontrolniKodProRIV	[37CF9B6B1F61]
http://linked.open...i/riv/nazevZdroje	Current Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	18
http://linked.open...iv/tvurceVysledku	Boštík, Pavel Kuča, Kamil Pikula, Jiří Pohanka, Miroslav Snopková, Svatava Šinkorová, Zuzana Havlíčková, Kateřina Fusek, Josef
http://linked.open...ain/vavai/riv/wos	000287301000005
http://linked.open...n/vavai/riv/zamer	Zdravotnická problematika ZHN
issn	0929-8673
number of pages	13 (xsd:int)
http://localhost/t...ganizacniJednotka	G44
is http://linked.open...avai/riv/vysledek of	Macrophage-assisted inflammation and pharmacological regulation of the cholinergic anti-inflammatory pathway

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