About: Role of γ-H2AX in DNA-damage response and its possible clinical applications

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About: Role of γ-H2AX in DNA-damage response and its possible clinical applications Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.vojenskaskola.cz/school/ud/fmhs/research_development/Documents/MMSL_2011_4_4_WWW.pdf
Description	The integrity of the human genome is constantly threatened by exogenous or endogenous genotoxic agents that cause DNA damage. The ionizing radiation (IR)-induced DNA double-strand breaks (DSBs) are considered as the most deleterious forms of DNA damage which could lead to genomic instability and to cancer development, if left unrepaired. The DNA damage response (DDR) is comprised of a network of proteins that cooperate to regulate cell cycle progression and repair of DNA lesions. Our understanding of molecular basis of repair processes and of functions of repair proteins, as well as understanding of chromatin modifications may provide new possibilities in improvement of cancer management. Phosphorylation of histone variant H2AX at serine 139 (γ-H2AX) and formation of γ-H2AX repair foci seems to be the most sensitive DNA damage marker in the chromatin flanking the free DNA double-stranded ends in DSBs. Monitoring of γ-H2AX levels can serve for early indication of cancer development, as biomarker of cancer therapy efficiency or as a biodosimetric marker of radiation exposure. The integrity of the human genome is constantly threatened by exogenous or endogenous genotoxic agents that cause DNA damage. The ionizing radiation (IR)-induced DNA double-strand breaks (DSBs) are considered as the most deleterious forms of DNA damage which could lead to genomic instability and to cancer development, if left unrepaired. The DNA damage response (DDR) is comprised of a network of proteins that cooperate to regulate cell cycle progression and repair of DNA lesions. Our understanding of molecular basis of repair processes and of functions of repair proteins, as well as understanding of chromatin modifications may provide new possibilities in improvement of cancer management. Phosphorylation of histone variant H2AX at serine 139 (γ-H2AX) and formation of γ-H2AX repair foci seems to be the most sensitive DNA damage marker in the chromatin flanking the free DNA double-stranded ends in DSBs. Monitoring of γ-H2AX levels can serve for early indication of cancer development, as biomarker of cancer therapy efficiency or as a biodosimetric marker of radiation exposure. (en)
Title	Role of γ-H2AX in DNA-damage response and its possible clinical applications Role of γ-H2AX in DNA-damage response and its possible clinical applications (en)
skos:prefLabel	Role of γ-H2AX in DNA-damage response and its possible clinical applications Role of γ-H2AX in DNA-damage response and its possible clinical applications (en)
skos:notation	RIV/60162694:G44__/11:00002498!RIV12-MO0-G44_____
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(MO0FVZ0000501)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Vávrová, Jiřina Tichý, Aleš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	227458
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/11:00002498
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DNA damage response; ionizing radiation; double-strand breaks; γ-H2AX; cancer biomarker; biodosimetry (en)
http://linked.open.../riv/klicoveSlovo	γ-H2AX cancer biomarker biodosimetry double-strand breaks DNA damage response ionizing radiation
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[80D591AEDAD3]
http://linked.open...i/riv/nazevZdroje	Military Medical Science Letters
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	80
http://linked.open...iv/tvurceVysledku	Novotná, Eva Tichý, Aleš Vávrová, Jiřina Foltánová, Karolína
http://linked.open...n/vavai/riv/zamer	Zdravotnická problematika ZHN
issn	0372-7025
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	G44
is http://linked.open...avai/riv/vysledek of	Role of γ-H2AX in DNA-damage response and its possible clinical applications

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