| Attributes | Values |
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| rdf:type
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| Description
| - Dvanáct bispyridiniových sloučenin nesoucích (E)-but-2-enový nebo (Z)-but-2-enový spojovací řetězec bylo testováno pomocí RP-HPLC metodiky na čistotu a lipofilitu. Byly nalezeny důležité intramolekulární interakce. (cs)
- New acetylcholinesterase reactivators with either a (E) or (Z)-but-2-ene connecting linker were recently prepared. The purity of the compounds was checked by HPLC and was found to be sufficient for in-vitro screening. All the discussed bispyridinium reactivators were analyzed by reversed-phase high performance liquid chromatography (RP-HPLC) to measure lipophilicity. The procedure was performed under isocratic conditions with methanol as organic modifier in the mobile phase using an end-capped non-polar C18 stationary phase RP column. Relationships between the lipophilicity (logarithmof the RP-HPLC capacity factor, log k) and chemical structures of the studied compounds are discussed. Lipophilicity was different for the (E) and (Z) compounds and varied among the compounds in each of these groups. The lipophilicity differences also indicated an apparent influence of intramolecular interactions. Lipophilicity calculations (log P/Clog P) by means of commonly used software were not successful due to the p
- New acetylcholinesterase reactivators with either a (E) or (Z)-but-2-ene connecting linker were recently prepared. The purity of the compounds was checked by HPLC and was found to be sufficient for in-vitro screening. All the discussed bispyridinium reactivators were analyzed by reversed-phase high performance liquid chromatography (RP-HPLC) to measure lipophilicity. The procedure was performed under isocratic conditions with methanol as organic modifier in the mobile phase using an end-capped non-polar C18 stationary phase RP column. Relationships between the lipophilicity (logarithmof the RP-HPLC capacity factor, log k) and chemical structures of the studied compounds are discussed. Lipophilicity was different for the (E) and (Z) compounds and varied among the compounds in each of these groups. The lipophilicity differences also indicated an apparent influence of intramolecular interactions. Lipophilicity calculations (log P/Clog P) by means of commonly used software were not successful due to the p (en)
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| Title
| - RP-HPLC lipophilicity determination of bispyridinium reactivators of acetylcholinesterase bearing a but-2-ene connecting linker
- RP-HPLC lipophilicity determination of bispyridinium reactivators of acetylcholinesterase bearing a but-2-ene connecting linker (en)
- RP-HPLC určení lipofility bispyridiniových reaktivátorů acetylcholinesterasy nesoucích but-2-enový spojovací řetězec (cs)
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| skos:prefLabel
| - RP-HPLC lipophilicity determination of bispyridinium reactivators of acetylcholinesterase bearing a but-2-ene connecting linker
- RP-HPLC lipophilicity determination of bispyridinium reactivators of acetylcholinesterase bearing a but-2-ene connecting linker (en)
- RP-HPLC určení lipofility bispyridiniových reaktivátorů acetylcholinesterasy nesoucích but-2-enový spojovací řetězec (cs)
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| skos:notation
| - RIV/60162694:G44__/08:00002001!RIV09-MO0-G44_____
|
| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GP305/07/P162), S, Z(MO0FVZ0000501)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/60162694:G44__/08:00002001
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - acetylcholinesterase; reactivator; RP-HPLC; purity; . lipophilicity (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Analytical and Bioanalytical Chemistry
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Dohnal, Jiří
- Jampílek, Josef
- Kuča, Kamil
- Musílek, Kamil
- Gunn-Moore, Frank
- Jun, Daniel
- Doležal, Mqrtin
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| http://linked.open...ain/vavai/riv/wos
| |
| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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| is http://linked.open...avai/riv/vysledek
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