About: Potency of five structurally different acetylcholinesterase reactivators to reactivate human brain cholinesterases inhibited by cyclosarin     Goto   Sponge   NotDistinct   Permalink

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  • Acetylcholinesterase (AChE; EC 3.1.1.7) reactivators are used as a part of the antidotes aimed for the treatment of organophosphorus pesticide and nerve agent intoxications. Cyclosarin is one member of the nerve agent family. In this work, we are interested in the comparison of reactivation potency of five structurally different AChE reactivators (pralidoxime, trimedoxime, methoxime, HS-6 and BI-6) to reactivate cyclosarin-inhibited cholinesterases of human brain. As resulted, bisquaternary monooxime reactivator BI-6 seems to be the most potent reactivator of cyclosarin-inhibited cholinesterases. Moreover, according to the obtained results, we can describe basic structural requirements, which are necessary for the efficacious reactivation process.
  • Acetylcholinesterase (AChE; EC 3.1.1.7) reactivators are used as a part of the antidotes aimed for the treatment of organophosphorus pesticide and nerve agent intoxications. Cyclosarin is one member of the nerve agent family. In this work, we are interested in the comparison of reactivation potency of five structurally different AChE reactivators (pralidoxime, trimedoxime, methoxime, HS-6 and BI-6) to reactivate cyclosarin-inhibited cholinesterases of human brain. As resulted, bisquaternary monooxime reactivator BI-6 seems to be the most potent reactivator of cyclosarin-inhibited cholinesterases. Moreover, according to the obtained results, we can describe basic structural requirements, which are necessary for the efficacious reactivation process. (en)
Title
  • Potency of five structurally different acetylcholinesterase reactivators to reactivate human brain cholinesterases inhibited by cyclosarin
  • Potency of five structurally different acetylcholinesterase reactivators to reactivate human brain cholinesterases inhibited by cyclosarin (en)
skos:prefLabel
  • Potency of five structurally different acetylcholinesterase reactivators to reactivate human brain cholinesterases inhibited by cyclosarin
  • Potency of five structurally different acetylcholinesterase reactivators to reactivate human brain cholinesterases inhibited by cyclosarin (en)
skos:notation
  • RIV/60162694:G44__/07:00001804!RIV10-MO0-G44_____
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MO0FVZ0000501)
http://linked.open...iv/cisloPeriodika
  • 5
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 442909
http://linked.open...ai/riv/idVysledku
  • RIV/60162694:G44__/07:00001804
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • cholinesterase; reactivators; cyclosarin; nerve agent; oxime (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [AA2C969C0E7C]
http://linked.open...i/riv/nazevZdroje
  • Clinical Toxicology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 45
http://linked.open...iv/tvurceVysledku
  • Cabal, Jiří
  • Hrabinová, Martina
  • Kuča, Kamil
  • Jun, Daniel
http://linked.open...ain/vavai/riv/wos
  • 000247731600018
http://linked.open...n/vavai/riv/zamer
issn
  • 1556-3650
number of pages
http://localhost/t...ganizacniJednotka
  • G44
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