About: In vitro reactivation potency of bispyridinium (E)-but-2-ene linked acetylcholinesterase reactivators against tabun-inhibited acetylcholinesterase

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About: In vitro reactivation potency of bispyridinium (E)-but-2-ene linked acetylcholinesterase reactivators against tabun-inhibited acetylcholinesterase Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Six potential bispyridinium (E)-but-2-ene linked AChE reactivators were tested on tabun-inhibited acetylcholinesterase in vitro. Their reactivation efficacy was compared to currently available AChE reactivators used in the case of organophosphorus intoxications - pralidoxime, HI-6 and obidoxime. According to the results obtained, (E)-1,4'-bis(4-hydroxyiminomethylpyridinium)but-2-ene dibromide (K075) seems to be the most potent reactivator of tabun - inhibited AChE. From the data, the reactivation potency of these compounds depends on structural factors such as the constitution of the linking chain between both pyridinium rings and the position of the oxime moiety at the pyridinium rings. Six potential bispyridinium (E)-but-2-ene linked AChE reactivators were tested on tabun-inhibited acetylcholinesterase in vitro. Their reactivation efficacy was compared to currently available AChE reactivators used in the case of organophosphorus intoxications - pralidoxime, HI-6 and obidoxime. According to the results obtained, (E)-1,4'-bis(4-hydroxyiminomethylpyridinium)but-2-ene dibromide (K075) seems to be the most potent reactivator of tabun - inhibited AChE. From the data, the reactivation potency of these compounds depends on structural factors such as the constitution of the linking chain between both pyridinium rings and the position of the oxime moiety at the pyridinium rings. (en)
Title	In vitro reactivation potency of bispyridinium (E)-but-2-ene linked acetylcholinesterase reactivators against tabun-inhibited acetylcholinesterase In vitro reactivation potency of bispyridinium (E)-but-2-ene linked acetylcholinesterase reactivators against tabun-inhibited acetylcholinesterase (en)
skos:prefLabel	In vitro reactivation potency of bispyridinium (E)-but-2-ene linked acetylcholinesterase reactivators against tabun-inhibited acetylcholinesterase In vitro reactivation potency of bispyridinium (E)-but-2-ene linked acetylcholinesterase reactivators against tabun-inhibited acetylcholinesterase (en)
skos:notation	RIV/60162694:G44__/07:00001771!RIV10-MO0-G44_____
http://linked.open...avai/riv/aktivita	V Z
http://linked.open...avai/riv/aktivity	V, Z(MO0FVZ0000501)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Jun, Daniel Kuča, Kamil Musílek, Kamil
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	425868
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/07:00001771
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	vitro; reactivation; potency; bispyridinium; -but-2-ene; linked; acetylcholinesterase; reactivators; against; tabun-inhibited; acetylcholinesterase (en)
http://linked.open.../riv/klicoveSlovo	bispyridinium vitro against tabun-inhibited potency acetylcholinesterase reactivation reactivators -but-2-ene linked
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[D2D79E874BD1]
http://linked.open...i/riv/nazevZdroje	Journal of Applied Biomedicine
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	5
http://linked.open...iv/tvurceVysledku	Doležal, Martin Kuča, Kamil Musílek, Kamil Jun, Daniel
http://linked.open...n/vavai/riv/zamer	Zdravotnická problematika ZHN
issn	1214-0287
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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