About: Novel series of bispyridinium compounds bearing a (Z)-but-2-ene Linker - Synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase

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About: Novel series of bispyridinium compounds bearing a (Z)-but-2-ene Linker - Synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Six novel AChE reactivators with a (Z)-but-2-ene linker were synthesized using the known synthetic pathways. Their ability to reactivate AChE, which had been previously inhibited by nerve agent tabun or pesticide paraoxon, was tested in vitro and compared to pralidoxime, HI-6, obidoxime, and K075. The novel synthesized compounds were found to be ineffective against GA-inhibited AChE but the ability of (Z)-1,4-bis(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide to reactivate paraoxoninhibited AChE was comparable with that of oxime K075. Notably, the oxime group in position four substantially increased the ability of the novel compounds to reactivate paraoxon-inhibited AChE. Six novel AChE reactivators with a (Z)-but-2-ene linker were synthesized using the known synthetic pathways. Their ability to reactivate AChE, which had been previously inhibited by nerve agent tabun or pesticide paraoxon, was tested in vitro and compared to pralidoxime, HI-6, obidoxime, and K075. The novel synthesized compounds were found to be ineffective against GA-inhibited AChE but the ability of (Z)-1,4-bis(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide to reactivate paraoxoninhibited AChE was comparable with that of oxime K075. Notably, the oxime group in position four substantially increased the ability of the novel compounds to reactivate paraoxon-inhibited AChE. (en) Byla připravena série nových reaktivátorů acetylcholinesterasy s (Z)-but-2-enovým spojovacím řetězcem - Syntéza a jejich testování proti tabunem a paraoxonem inhibované acetylcholinesterase. (cs)
Title	Novel series of bispyridinium compounds bearing a (Z)-but-2-ene Linker - Synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase Novel series of bispyridinium compounds bearing a (Z)-but-2-ene Linker - Synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase (en) Série nových reaktivátorů acetylcholinesterasy s (Z)-but-2-enovým spojovacím řetězcem - Syntéza a jejich testování proti tabunem a paraoxonem inhibované acetylcholinesterase (cs)
skos:prefLabel	Novel series of bispyridinium compounds bearing a (Z)-but-2-ene Linker - Synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase Novel series of bispyridinium compounds bearing a (Z)-but-2-ene Linker - Synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase (en) Série nových reaktivátorů acetylcholinesterasy s (Z)-but-2-enovým spojovacím řetězcem - Syntéza a jejich testování proti tabunem a paraoxonem inhibované acetylcholinesterase (cs)
skos:notation	RIV/60162694:G44__/07:00001766!RIV08-MO0-G44_____
http://linked.open.../vavai/riv/strany	3172-3176
http://linked.open...avai/riv/aktivita	V Z
http://linked.open...avai/riv/aktivity	V, Z(MO0FVZ0000501)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Jun, Daniel Kuča, Kamil Musílek, Kamil
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	437922
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/07:00001766
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Acetylcholinesterase; Reactivation; Nerve agent; Tabun; Pesticide; Paraoxon; Reactivator; Oxime (en)
http://linked.open.../riv/klicoveSlovo	Tabun Pesticide Reactivation Acetylcholinesterase Reactivator Paraoxon Nerve agent Oxime
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[3C5CB2804894]
http://linked.open...i/riv/nazevZdroje	Bioorganic and Medicinal Chemistry Letters
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	17
http://linked.open...iv/tvurceVysledku	Doležal, Martin Dohnal, Vlastimil Kuča, Kamil Musílek, Kamil Jun, Daniel Opletalová, Veronika Holas, Ondřej
http://linked.open...n/vavai/riv/zamer	Zdravotnická problematika ZHN
issn	0960-894X
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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