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Description
  • Following sarin intoxication, blood cholinesterases were increased after the obidoxime administration. Intoxication with VX showed a similar picture but reactivation after the obidoxime administration was greater. In soman intoxication, the picture of cholinesterase changes was similar during the first 30 min of treatment. The increase in AChE activity following obidoxime administration was not as high as in the case of sarin and VX intoxication. Thus, the reactivation efficacy of obidoxime during nerve agent intoxication indicates that its repeated administration could be easily monitored using the reactivation test.
  • Following sarin intoxication, blood cholinesterases were increased after the obidoxime administration. Intoxication with VX showed a similar picture but reactivation after the obidoxime administration was greater. In soman intoxication, the picture of cholinesterase changes was similar during the first 30 min of treatment. The increase in AChE activity following obidoxime administration was not as high as in the case of sarin and VX intoxication. Thus, the reactivation efficacy of obidoxime during nerve agent intoxication indicates that its repeated administration could be easily monitored using the reactivation test. (en)
  • Po otravě sarinem byla aktivitza cholinesteráz zvýšena po podání obidoximu. Intoxikace látkou VX vykázala obdobný obrázek, ale reaktivace po podání obidoximu byla větší. Po intoxikaci somanem byl vývoj změn aktivity cholinesteráz podobný během prvních 30 minut po podání antidot. Zvýšení aktivity AChE po podání obidoximu však nebylo tak vysoké jako v případě otravy sarinem a látkou VX. Reaktivační účinnost obidoximu během intoxikace nervově paralytickými látkami ukázala, že jeho opakované podání by mohlo být snadno monitorováno pomocí reaktivačního testu (cs)
Title
  • Vyhodnocení reaktivačního testu u anestezovaných psů po experimentální intoxikaci nervově paralytickými látkami (cs)
  • Evaluation of reactivation test in anaesthetized dogs with experimental intoxication with nerve agents
  • Evaluation of reactivation test in anaesthetized dogs with experimental intoxication with nerve agents (en)
skos:prefLabel
  • Vyhodnocení reaktivačního testu u anestezovaných psů po experimentální intoxikaci nervově paralytickými látkami (cs)
  • Evaluation of reactivation test in anaesthetized dogs with experimental intoxication with nerve agents
  • Evaluation of reactivation test in anaesthetized dogs with experimental intoxication with nerve agents (en)
skos:notation
  • RIV/60162694:G44__/06:00001874!RIV08-MO0-G44_____
http://linked.open.../vavai/riv/strany
  • 439-443
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MO0FVZ0000501)
http://linked.open...iv/cisloPeriodika
  • 5
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 474730
http://linked.open...ai/riv/idVysledku
  • RIV/60162694:G44__/06:00001874
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • dog; sarin; soman; VX; intoxication; blood; cholinesterases; reactivation (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [0DDFF5C23AD4]
http://linked.open...i/riv/nazevZdroje
  • Journal of Applied Toxicology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 26
http://linked.open...iv/tvurceVysledku
  • Bajgar, Jiří
  • Kuča, Kamil
  • Fusek, Josef
  • Jun, Daniel
  • Bartošová, Lucie
http://linked.open...n/vavai/riv/zamer
issn
  • 0260-437X
number of pages
http://localhost/t...ganizacniJednotka
  • G44
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