About: Nature’s timepiece – molecular coordination of metabolism and impact on aging

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.mdpi.com/1422-0067/14/2/3026
Description	Circadian rhythms are found in almost all organisms from cyanobacteria to humans, where most behavioral and physiological processes occur over a period of approximately 24 h in tandem with the day/night cycles. The role of circadian clocks in regulating metabolism and consequently cellular and metabolic homeostasis is an intensively investigated area of research. A fully functional circadian clock would be vital to timing events in general metabolism, thus contributing to metabolic health and to ensure an increased “health-span during the process of aging. Here, we present recent evidence of links between clocks, cellular metabolism, aging and oxidative stress. In the light of these data, we arrive at conceptual generalizations of this relationship across the spectrum of model organisms from fruit flies to mammals. Circadian rhythms are found in almost all organisms from cyanobacteria to humans, where most behavioral and physiological processes occur over a period of approximately 24 h in tandem with the day/night cycles. The role of circadian clocks in regulating metabolism and consequently cellular and metabolic homeostasis is an intensively investigated area of research. A fully functional circadian clock would be vital to timing events in general metabolism, thus contributing to metabolic health and to ensure an increased “health-span during the process of aging. Here, we present recent evidence of links between clocks, cellular metabolism, aging and oxidative stress. In the light of these data, we arrive at conceptual generalizations of this relationship across the spectrum of model organisms from fruit flies to mammals. (en)
Title	Nature’s timepiece – molecular coordination of metabolism and impact on aging Nature’s timepiece – molecular coordination of metabolism and impact on aging (en)
skos:prefLabel	Nature’s timepiece – molecular coordination of metabolism and impact on aging Nature’s timepiece – molecular coordination of metabolism and impact on aging (en)
skos:notation	RIV/60077344:_____/13:00388970!RIV14-AV0-60077344
http://linked.open...avai/predkladatel	Biologické centrum AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP501/10/1215)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Bednářová, Andrea Kodrík, Dalibor
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	90864
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/13:00388970
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	aging; circadian clocks; cellular metabolism (en)
http://linked.open.../riv/klicoveSlovo	cellular metabolism circadian clocks aging
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[64460BADD0EC]
http://linked.open...i/riv/nazevZdroje	International Journal of Molecular Sciences
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Stress hormones and their potential usage in insect pest control
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	14
http://linked.open...iv/tvurceVysledku	Kodrík, Dalibor Krishnan, N. Bednářová, Andrea
http://linked.open...ain/vavai/riv/wos	000315397900045
issn	1422-0067
number of pages	24 (xsd:int)
http://bibframe.org/vocab/doi	10.3390/ijms14023026

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