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  • Circadian rhythms are found in almost all organisms from cyanobacteria to humans, where most behavioral and physiological processes occur over a period of approximately 24 h in tandem with the day/night cycles. The role of circadian clocks in regulating metabolism and consequently cellular and metabolic homeostasis is an intensively investigated area of research. A fully functional circadian clock would be vital to timing events in general metabolism, thus contributing to metabolic health and to ensure an increased “health-span during the process of aging. Here, we present recent evidence of links between clocks, cellular metabolism, aging and oxidative stress. In the light of these data, we arrive at conceptual generalizations of this relationship across the spectrum of model organisms from fruit flies to mammals.
  • Circadian rhythms are found in almost all organisms from cyanobacteria to humans, where most behavioral and physiological processes occur over a period of approximately 24 h in tandem with the day/night cycles. The role of circadian clocks in regulating metabolism and consequently cellular and metabolic homeostasis is an intensively investigated area of research. A fully functional circadian clock would be vital to timing events in general metabolism, thus contributing to metabolic health and to ensure an increased “health-span during the process of aging. Here, we present recent evidence of links between clocks, cellular metabolism, aging and oxidative stress. In the light of these data, we arrive at conceptual generalizations of this relationship across the spectrum of model organisms from fruit flies to mammals. (en)
Title
  • Nature’s timepiece – molecular coordination of metabolism and impact on aging
  • Nature’s timepiece – molecular coordination of metabolism and impact on aging (en)
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  • Nature’s timepiece – molecular coordination of metabolism and impact on aging
  • Nature’s timepiece – molecular coordination of metabolism and impact on aging (en)
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  • RIV/60077344:_____/13:00388970!RIV14-AV0-60077344
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  • I, P(GAP501/10/1215)
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  • 2
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  • 90864
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  • RIV/60077344:_____/13:00388970
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  • aging; circadian clocks; cellular metabolism (en)
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  • CH - Švýcarská konfederace
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  • [64460BADD0EC]
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  • International Journal of Molecular Sciences
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  • 14
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  • Kodrík, Dalibor
  • Krishnan, N.
  • Bednářová, Andrea
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  • 000315397900045
issn
  • 1422-0067
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  • 10.3390/ijms14023026
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