About: Cell-Type Specific DNA Methylation Patterns Define Human Breast Cellular Identity

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	DNA methylation plays a role in a variety of biological processes including embryonic development, imprinting, X-chromosome inactivation, and stem cell differentiation. Tissue specific differential methylation has also been well characterized. We sought to extend these studies to create a map of differential DNA methylation between different cell types derived from a single tissue. Using three pairs of isogenic human mammary epithelial and fibroblast cells, promoter region DNA methylation was characterized using MeDIP coupled to microarray analysis. Comparison of DNA methylation between these cell types revealed nearly three thousand cell-type specific differentially methylated regions (ctDMRs). MassARRAY was performed upon 87 ctDMRs to confirm and quantify differential DNA methylation.Each of the examined regions exhibited statistically significant differences ranging from 10-70%. Gene ontology analysis revealed the overrepresentation of many transcription factors involved in developmental processes. DNA methylation plays a role in a variety of biological processes including embryonic development, imprinting, X-chromosome inactivation, and stem cell differentiation. Tissue specific differential methylation has also been well characterized. We sought to extend these studies to create a map of differential DNA methylation between different cell types derived from a single tissue. Using three pairs of isogenic human mammary epithelial and fibroblast cells, promoter region DNA methylation was characterized using MeDIP coupled to microarray analysis. Comparison of DNA methylation between these cell types revealed nearly three thousand cell-type specific differentially methylated regions (ctDMRs). MassARRAY was performed upon 87 ctDMRs to confirm and quantify differential DNA methylation.Each of the examined regions exhibited statistically significant differences ranging from 10-70%. Gene ontology analysis revealed the overrepresentation of many transcription factors involved in developmental processes. (en)
Title	Cell-Type Specific DNA Methylation Patterns Define Human Breast Cellular Identity Cell-Type Specific DNA Methylation Patterns Define Human Breast Cellular Identity (en)
skos:prefLabel	Cell-Type Specific DNA Methylation Patterns Define Human Breast Cellular Identity Cell-Type Specific DNA Methylation Patterns Define Human Breast Cellular Identity (en)
skos:notation	RIV/60077344:_____/12:00391196!RIV13-AV0-60077344
http://linked.open...avai/predkladatel	Biologické centrum AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	I Z
http://linked.open...avai/riv/aktivity	I, Z(AV0Z50510513)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Novák, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	126228
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/12:00391196
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	MAMMARY EPITHELIAL-CELLS; PLURIPOTENT STEM-CELLS; CPG ISLAND SHORES (en)
http://linked.open.../riv/klicoveSlovo	CPG ISLAND SHORES MAMMARY EPITHELIAL-CELLS PLURIPOTENT STEM-CELLS
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[53B9CDB71E6D]
http://linked.open...i/riv/nazevZdroje	PLoS ONE
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Novák, Petr Ehrich, M. Futscher, B. W. Garbe, J. C. Jensen, T. J. Munoz-Rodriguez, J. L. Stampfer, M. R.
http://linked.open...ain/vavai/riv/wos	000312794500139
http://linked.open...n/vavai/riv/zamer	Výzkum struktury genetické informace rostlin a jejich patogenů na molekulární úrovni, indukce a analýza cílených změn genomu a plastomu a studium fotosyntetických procesů a projevů dědičnosti v interakci s prostředím a patogeny
issn	1932-6203
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1371/journal.pone.0052299
is http://linked.open...avai/riv/vysledek of	Cell-Type Specific DNA Methylation Patterns Define Human Breast Cellular Identity

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