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  • Adenosine (Ado) is a crucial metabolite that influences proliferation of several vertebrate and invertebrate cells. Key proteins regulating Ado signaling, transport and metabolism are conserved among vertebrates and invertebrates. Here we show that Ado negatively influences viability, changes morphology and mitochondrial polarity of the Drosophila imaginal disc cell line (Cl.8ţ) via a mechanism exclusively dependent on cellular Ado uptake. High transport of Ado is followed by ATP production as a part of Ado salvation, which at higher concentrations may interfere with cellular homeostasis. In contrast, hematopoietic cell line Mbn2, which grows well in high Ado concentration, preferentially uses adenosine deaminase as a part of the purine catabolic pathway. Our results show that different types of Drosophila cell lines use different pathways for Ado conversion and suggest that such differences may be an important part of complex mechanisms maintaining energy homeostasis in the body.
  • Adenosine (Ado) is a crucial metabolite that influences proliferation of several vertebrate and invertebrate cells. Key proteins regulating Ado signaling, transport and metabolism are conserved among vertebrates and invertebrates. Here we show that Ado negatively influences viability, changes morphology and mitochondrial polarity of the Drosophila imaginal disc cell line (Cl.8ţ) via a mechanism exclusively dependent on cellular Ado uptake. High transport of Ado is followed by ATP production as a part of Ado salvation, which at higher concentrations may interfere with cellular homeostasis. In contrast, hematopoietic cell line Mbn2, which grows well in high Ado concentration, preferentially uses adenosine deaminase as a part of the purine catabolic pathway. Our results show that different types of Drosophila cell lines use different pathways for Ado conversion and suggest that such differences may be an important part of complex mechanisms maintaining energy homeostasis in the body. (en)
Title
  • Differential response of Drosophila cell lines to extracellular adenosine
  • Differential response of Drosophila cell lines to extracellular adenosine (en)
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  • Differential response of Drosophila cell lines to extracellular adenosine
  • Differential response of Drosophila cell lines to extracellular adenosine (en)
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  • RIV/60077344:_____/12:00376113!RIV13-AV0-60077344
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  • I, P(KJB501410801), P(LC06077), Z(AV0Z50070508)
http://linked.open...iv/cisloPeriodika
  • 5
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  • 131267
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  • RIV/60077344:_____/12:00376113
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  • adenosine recycling; nucleoside transport; Mbn2 (en)
http://linked.open.../riv/klicoveSlovo
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  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [A00179761D86]
http://linked.open...i/riv/nazevZdroje
  • Insect Biochemistry and Molecular Biology
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  • 42
http://linked.open...iv/tvurceVysledku
  • Kučerová, Lucie
  • Steinbauerová, Veronika
  • Šimek, Petr
  • Žurovec, Michal
  • Brož, Václav
  • Fleischmannová, J.
  • Šandová, Kateřina
http://linked.open...ain/vavai/riv/wos
  • 000302515800002
http://linked.open...n/vavai/riv/zamer
issn
  • 0965-1748
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.ibmb.2012.01.002
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