About: Differential response of Drosophila cell lines to extracellular adenosine

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S0965174812000033
Description	Adenosine (Ado) is a crucial metabolite that influences proliferation of several vertebrate and invertebrate cells. Key proteins regulating Ado signaling, transport and metabolism are conserved among vertebrates and invertebrates. Here we show that Ado negatively influences viability, changes morphology and mitochondrial polarity of the Drosophila imaginal disc cell line (Cl.8ţ) via a mechanism exclusively dependent on cellular Ado uptake. High transport of Ado is followed by ATP production as a part of Ado salvation, which at higher concentrations may interfere with cellular homeostasis. In contrast, hematopoietic cell line Mbn2, which grows well in high Ado concentration, preferentially uses adenosine deaminase as a part of the purine catabolic pathway. Our results show that different types of Drosophila cell lines use different pathways for Ado conversion and suggest that such differences may be an important part of complex mechanisms maintaining energy homeostasis in the body. Adenosine (Ado) is a crucial metabolite that influences proliferation of several vertebrate and invertebrate cells. Key proteins regulating Ado signaling, transport and metabolism are conserved among vertebrates and invertebrates. Here we show that Ado negatively influences viability, changes morphology and mitochondrial polarity of the Drosophila imaginal disc cell line (Cl.8ţ) via a mechanism exclusively dependent on cellular Ado uptake. High transport of Ado is followed by ATP production as a part of Ado salvation, which at higher concentrations may interfere with cellular homeostasis. In contrast, hematopoietic cell line Mbn2, which grows well in high Ado concentration, preferentially uses adenosine deaminase as a part of the purine catabolic pathway. Our results show that different types of Drosophila cell lines use different pathways for Ado conversion and suggest that such differences may be an important part of complex mechanisms maintaining energy homeostasis in the body. (en)
Title	Differential response of Drosophila cell lines to extracellular adenosine Differential response of Drosophila cell lines to extracellular adenosine (en)
skos:prefLabel	Differential response of Drosophila cell lines to extracellular adenosine Differential response of Drosophila cell lines to extracellular adenosine (en)
skos:notation	RIV/60077344:_____/12:00376113!RIV13-AV0-60077344
http://linked.open...avai/predkladatel	Biologické centrum AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(KJB501410801), P(LC06077), Z(AV0Z50070508)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Steinbauerová, Veronika Šimek, Petr Žurovec, Michal Kučerová, Lucie Brož, Václav Šandová, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	131267
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/12:00376113
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	adenosine recycling; nucleoside transport; Mbn2 (en)
http://linked.open.../riv/klicoveSlovo	Mbn2 adenosine recycling nucleoside transport
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[A00179761D86]
http://linked.open...i/riv/nazevZdroje	Insect Biochemistry and Molecular Biology
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Chemical Genetics Physiological roles of adenosine in Drosophila.
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	42
http://linked.open...iv/tvurceVysledku	Kučerová, Lucie Steinbauerová, Veronika Šimek, Petr Žurovec, Michal Brož, Václav Fleischmannová, J. Šandová, Kateřina
http://linked.open...ain/vavai/riv/wos	000302515800002
http://linked.open...n/vavai/riv/zamer	Study of the regulation of insect organism, dynamics of insect populations and function of insects in ecosystems
issn	0965-1748
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.ibmb.2012.01.002
is http://linked.open...avai/riv/vysledek of	Differential response of Drosophila cell lines to extracellular adenosine

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