About: Analysis of blastomogenic activity of mammal carcinogens in Drosophila using the wts (P4) allele and RNA interference-induced P53 silencing

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About: Analysis of blastomogenic activity of mammal carcinogens in Drosophila using the wts (P4) allele and RNA interference-induced P53 silencing Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The test for somatic mutagenesis and recombination in Drosophila is one of the widely used approaches for determination of possible carcinogenic effects of chemical compounds. The use of heterozygotes for mutant tumor suppressor gene wts enables more direct evaluation of the blastomogenic effects of chemical compounds, by tumor formation in the adult flies. This study presents evaluation of the SMART effectiveness upon the use of Drosophila heterozygotes for the wts (P4) gene, first included into the test system. The increase of the test resolution capacity compared to the literature data for the wts (P2) allele was observed. Using wts (P4) heterozygotes, a total of 20 carcinogenic compounds, and their slightly carcinogenic and non-carcinogenic analogs were tested. Specificity of the method was about 100%, and sensitivity depended on the type of the agent tested. The latter was absolute for the direct action carcinogens, with respect to carcinogens, requiring the metabolic activation. The test for somatic mutagenesis and recombination in Drosophila is one of the widely used approaches for determination of possible carcinogenic effects of chemical compounds. The use of heterozygotes for mutant tumor suppressor gene wts enables more direct evaluation of the blastomogenic effects of chemical compounds, by tumor formation in the adult flies. This study presents evaluation of the SMART effectiveness upon the use of Drosophila heterozygotes for the wts (P4) gene, first included into the test system. The increase of the test resolution capacity compared to the literature data for the wts (P2) allele was observed. Using wts (P4) heterozygotes, a total of 20 carcinogenic compounds, and their slightly carcinogenic and non-carcinogenic analogs were tested. Specificity of the method was about 100%, and sensitivity depended on the type of the agent tested. The latter was absolute for the direct action carcinogens, with respect to carcinogens, requiring the metabolic activation. (en)
Title	Analysis of blastomogenic activity of mammal carcinogens in Drosophila using the wts (P4) allele and RNA interference-induced P53 silencing Analysis of blastomogenic activity of mammal carcinogens in Drosophila using the wts (P4) allele and RNA interference-induced P53 silencing (en)
skos:prefLabel	Analysis of blastomogenic activity of mammal carcinogens in Drosophila using the wts (P4) allele and RNA interference-induced P53 silencing Analysis of blastomogenic activity of mammal carcinogens in Drosophila using the wts (P4) allele and RNA interference-induced P53 silencing (en)
skos:notation	RIV/60077344:_____/11:00368651!RIV12-AV0-60077344
http://linked.open...avai/predkladatel	Biologické centrum AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAA500070601), Z(AV0Z50070508)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Sidorov, Roman
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	185612
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/11:00368651
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Drosophila (en)
http://linked.open.../riv/klicoveSlovo	Drosophila
http://linked.open...odStatuVydavatele	RU - Ruská federace
http://linked.open...ontrolniKodProRIV	[C7190A0243F9]
http://linked.open...i/riv/nazevZdroje	Russian Journal of Genetics
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular mechanisms for the growth factor action of two Drosophila protein families
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	47
http://linked.open...iv/tvurceVysledku	Belitsky, G. A. Kirsanov, K. I. Lesovaya, E. A. Sidorov, Roman Yakubovskaya, M. G.
http://linked.open...ain/vavai/riv/wos	000289574400004
http://linked.open...n/vavai/riv/zamer	Study of the regulation of insect organism, dynamics of insect populations and function of insects in ecosystems
issn	1022-7954
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1134/S1022795411040065
is http://linked.open...avai/riv/vysledek of	Analysis of blastomogenic activity of mammal carcinogens in Drosophila using the wts (P4) allele and RNA interference-induced P53 silencing Analysis of blastomogenic activity of mammal carcinogens in Drosophila using the wts (P4) allele and RNA interference-induced P53 silencing

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