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  • Most eukaryotes elongate chromosome ends with telomerase that repeatedly adds copies of the short telomeric DNA sequence to the chromosome end. While there is strict conservation of telomeric sequence repeat in most species, the repeat unit has changed over evolutionary time. Lack of the predominant telomeric sequence in a species does not, however, signify that telomerase-generated terminal sequences are missing. Conversely, the presence of a canonical telomeric sequence does not necessarily indicate telomerase as a telomere maintenance mechanism. Although telomerase may have been the mechanism of telomere maintenance of the last common eukaryotic ancestor, it is not the only mechanism used to maintain chromosome length. Telomerase has been lost a few times in the evolution of plants and animals. During insect evolution, for example, telomerase has been lost at least six times. Here, we discuss telomere maintenance mechanisms that replaced telomerase in telomere length maintenance.
  • Most eukaryotes elongate chromosome ends with telomerase that repeatedly adds copies of the short telomeric DNA sequence to the chromosome end. While there is strict conservation of telomeric sequence repeat in most species, the repeat unit has changed over evolutionary time. Lack of the predominant telomeric sequence in a species does not, however, signify that telomerase-generated terminal sequences are missing. Conversely, the presence of a canonical telomeric sequence does not necessarily indicate telomerase as a telomere maintenance mechanism. Although telomerase may have been the mechanism of telomere maintenance of the last common eukaryotic ancestor, it is not the only mechanism used to maintain chromosome length. Telomerase has been lost a few times in the evolution of plants and animals. During insect evolution, for example, telomerase has been lost at least six times. Here, we discuss telomere maintenance mechanisms that replaced telomerase in telomere length maintenance. (en)
Title
  • Telomore maintenance on organisms without telomerase
  • Telomore maintenance on organisms without telomerase (en)
skos:prefLabel
  • Telomore maintenance on organisms without telomerase
  • Telomore maintenance on organisms without telomerase (en)
skos:notation
  • RIV/60077344:_____/11:00364291!RIV12-AV0-60077344
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
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  • Z(AV0Z50070508)
http://linked.open...vai/riv/dodaniDat
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http://linked.open...iv/duvernostUdaju
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  • 234573
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  • RIV/60077344:_____/11:00364291
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  • telomere (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [ED493C41EC6D]
http://linked.open...i/riv/mistoVydani
  • Rijeka
http://linked.open...i/riv/nazevZdroje
  • DNA Replication-Current Advances
http://linked.open...in/vavai/riv/obor
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http://linked.open...v/pocetStranKnihy
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Mason, J. M.
  • Reddy, H. M.
  • Čapková Frydrychová, Radmila
http://linked.open...n/vavai/riv/zamer
number of pages
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  • InTech
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  • 978-953-307-593-8
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