About: Equilibrative nucleoside transporter 2 regulates olfactory memory and synaptic function in Drosophila

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Nucleoside transporters are evolutionarily conserved proteins that are essential for normal cellular function. In the present study, we examined the role of equilibrative nucleoside transporter 2 (ent2) in Drosophila. Null mutants of ent2 are lethal during late larval/early pupal stages, indicating that ent2 is essential for normal development. Hypomorphic mutant alleles of ent2, however, are viable and exhibit reduced associative learning. We additionally used RNA interference to knock down ent2 expression in specific regions of the CNS and show that ent2 is required in the alpha/beta lobes of the mushroom bodies and the antennal lobes. To determine whether the observed behavioral defects are attributable to defects in synaptic transmission, we examined transmitter release at the larval neuromuscular junction (NMJ). Excitatory junction potentials were significantly elevated in ent2 mutants, whereas paired-pulse plasticity was reduced. Nucleoside transporters are evolutionarily conserved proteins that are essential for normal cellular function. In the present study, we examined the role of equilibrative nucleoside transporter 2 (ent2) in Drosophila. Null mutants of ent2 are lethal during late larval/early pupal stages, indicating that ent2 is essential for normal development. Hypomorphic mutant alleles of ent2, however, are viable and exhibit reduced associative learning. We additionally used RNA interference to knock down ent2 expression in specific regions of the CNS and show that ent2 is required in the alpha/beta lobes of the mushroom bodies and the antennal lobes. To determine whether the observed behavioral defects are attributable to defects in synaptic transmission, we examined transmitter release at the larval neuromuscular junction (NMJ). Excitatory junction potentials were significantly elevated in ent2 mutants, whereas paired-pulse plasticity was reduced. (en)
Title	Equilibrative nucleoside transporter 2 regulates olfactory memory and synaptic function in Drosophila Equilibrative nucleoside transporter 2 regulates olfactory memory and synaptic function in Drosophila (en)
skos:prefLabel	Equilibrative nucleoside transporter 2 regulates olfactory memory and synaptic function in Drosophila Equilibrative nucleoside transporter 2 regulates olfactory memory and synaptic function in Drosophila (en)
skos:notation	RIV/60077344:_____/10:00355637!RIV11-MSM-60077344
http://linked.open...avai/riv/aktivita	I P V Z
http://linked.open...avai/riv/aktivity	I, P(LC06077), V, Z(AV0Z50070508)
http://linked.open...iv/cisloPeriodika	14
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Pavlová, Eva Žurovec, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	257426
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/10:00355637
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Drosophila (en)
http://linked.open.../riv/klicoveSlovo	Drosophila
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[BEC39284837E]
http://linked.open...i/riv/nazevZdroje	Journal of Neuroscience
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Chemical Genetics
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	30
http://linked.open...iv/tvurceVysledku	Žurovec, Michal Doleželová, Eva Knight, D. Boulianne, G. L. Charlton, M. P. Harvey, P. J. Iliadi, K. G. Iliadi, N. Klose, M. K.
http://linked.open...ain/vavai/riv/wos	000276414800025
http://linked.open...n/vavai/riv/zamer	Study of the regulation of insect organism, dynamics of insect populations and function of insects in ecosystems
issn	0270-6474
number of pages	11 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Equilibrative nucleoside transporter 2 regulates olfactory memory and synaptic function in Drosophila Equilibrative nucleoside transporter 2 regulates olfactory memory and synaptic function in Drosophila Equilibrative nucleoside transporter 2 regulates olfactory memory and synaptic function in Drosophila

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