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rdf:type
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Description
| - The absence of a general gene-targeting system for systematic reverse genetic studies has been a significant limitation in silkworm research. The authors performed direct zinc finger nuclease mRNA injection to /B. mori/ embryos and induced mutations in an epidermal color gene /BmBLOS2. /The results suggest that the /B. mori/ double-strand break repair system relies on microhomologies rather than on a ligase IV-dependent mechanism typical for /Drosophila/. The observed frequency of germline mutations was sufficient for future use in gene targeting relying solely on molecular methods of screening.
- The absence of a general gene-targeting system for systematic reverse genetic studies has been a significant limitation in silkworm research. The authors performed direct zinc finger nuclease mRNA injection to /B. mori/ embryos and induced mutations in an epidermal color gene /BmBLOS2. /The results suggest that the /B. mori/ double-strand break repair system relies on microhomologies rather than on a ligase IV-dependent mechanism typical for /Drosophila/. The observed frequency of germline mutations was sufficient for future use in gene targeting relying solely on molecular methods of screening. (en)
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Title
| - Targeted mutagenesis in the silkworm Bombyx mori using zinc finger nuclease mRNA injection
- Targeted mutagenesis in the silkworm Bombyx mori using zinc finger nuclease mRNA injection (en)
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skos:prefLabel
| - Targeted mutagenesis in the silkworm Bombyx mori using zinc finger nuclease mRNA injection
- Targeted mutagenesis in the silkworm Bombyx mori using zinc finger nuclease mRNA injection (en)
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skos:notation
| - RIV/60077344:_____/10:00347925!RIV11-GA0-60077344
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GAP305/10/2406), P(IAA500070601), P(LC06077), Z(AV0Z50070508)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/60077344:_____/10:00347925
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - gene targeting; nonhomologous and joining; Lepidoptera (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Insect Biochemistry and Molecular Biology
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Žurovec, Michal
- Sezutsu, H.
- Takasu, Yoko
- Tamura, T.
- Uchino, K.
- Beumer, K.
- Carroll, D.
- Kobayashi, I.
- Sajwan, S.
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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is http://linked.open...avai/riv/vysledek
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