About: Tick-borne encephalitis virus infection of cultured mouse macrophages

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The interactions of tick-borne encephalitis virus (TBEV) with mouse macrophages were studied at electron microscopic level. The macrophages were sensitive to infection with TBEV strain Hypr (a highly neuroinvasive and neurovirulent strain for laboratory mice). However, these macrophage cells remained morphologically inactivated. Viral particles were located mainly in the ER. No virus production was observed in cells infected with the attenuated, non-neuroinvasive TBEV strain 263. In this case, the infection led to a clear morphological activation of the macrophages. The virus replication process in mouse macrophage cells might be different from that in other mammalian cell lines. Moreover, different TBEV strains exhibited a different interaction with the host macrophages. The inability of strain 263 to replicate in mouse macrophages as the first site of significant viral replication in vivo could be associated with the inability of this strain to establish a serious infection in mice. The interactions of tick-borne encephalitis virus (TBEV) with mouse macrophages were studied at electron microscopic level. The macrophages were sensitive to infection with TBEV strain Hypr (a highly neuroinvasive and neurovirulent strain for laboratory mice). However, these macrophage cells remained morphologically inactivated. Viral particles were located mainly in the ER. No virus production was observed in cells infected with the attenuated, non-neuroinvasive TBEV strain 263. In this case, the infection led to a clear morphological activation of the macrophages. The virus replication process in mouse macrophage cells might be different from that in other mammalian cell lines. Moreover, different TBEV strains exhibited a different interaction with the host macrophages. The inability of strain 263 to replicate in mouse macrophages as the first site of significant viral replication in vivo could be associated with the inability of this strain to establish a serious infection in mice. (en)
Title	Tick-borne encephalitis virus infection of cultured mouse macrophages Tick-borne encephalitis virus infection of cultured mouse macrophages (en)
skos:prefLabel	Tick-borne encephalitis virus infection of cultured mouse macrophages Tick-borne encephalitis virus infection of cultured mouse macrophages (en)
skos:notation	RIV/60077344:_____/09:00334900!RIV10-MSM-60077344
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA524/06/1479), P(LC06009), Z(AV0Z60220518), Z(MSM6007665801)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Šťastná, Hana Tesařová, Martina Grubhoffer, Libor Růžek, Daniel Vancová, Marie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	346330
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/09:00334900
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	tick-borne encephalitis; macrophages; electron microscopy (en)
http://linked.open.../riv/klicoveSlovo	electron microscopy tick-borne encephalitis macrophages
http://linked.open...odStatuVydavatele	SZ - Svazijské království
http://linked.open...ontrolniKodProRIV	[D42B35D2CB85]
http://linked.open...i/riv/nazevZdroje	Intervirology
http://linked.open...in/vavai/riv/obor	GJ
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre for molecular ecology of vectors and pathogens Comparative analysis of differential gene expression in Ixodes ricinus tick after infection with TBE virus and LB spirochetes
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	52
http://linked.open...iv/tvurceVysledku	Grubhoffer, Libor Růžek, Daniel Vancová, Marie Tesařová, Martina Ahantarig, A. Šťastná, Hana Janowitz, A.
http://linked.open...ain/vavai/riv/wos	000269788600008
http://linked.open...n/vavai/riv/zamer	Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni EKOLOGICKÉ, EVOLUČNÍ A EXPERIMENTÁLNĚ BIOLOGICKÉ PŘÍSTUPY KE STUDIU VZNIKU A VÝZNAMU BIODIVERZITY
issn	0300-5526
number of pages	8 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Tick-borne encephalitis virus infection of cultured mouse macrophages Tick-borne encephalitis virus infection of cultured mouse macrophages Tick-borne encephalitis virus infection of cultured mouse macrophages Tick-borne encephalitis virus infection of cultured mouse macrophages

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