About: The effect of down-regulation of mitochondrial RNA-binding proteins MRP1 and MRP2 on respiratory complexes in procyclic Trypanosoma brucei

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About: The effect of down-regulation of mitochondrial RNA-binding proteins MRP1 and MRP2 on respiratory complexes in procyclic Trypanosoma brucei Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	MRP1 a MRP2 jsou multifunkční, mitochondriální RNA-vážící proteiny s regulační rolí v editování RNA a možnou rolí ve zpracování RNA u Trypanosoma brucei. Umlčení genů pro MRP1 a/nebo MRP2 metodou interference RNA ovlivnilo skládání a funkčnost dýchacích komplexů. Absence několika podjednotek komplexů I, III a IV vyústila v jejich desintegraci a následný pokles specifických aktivit a rovněž způsobila signifikantní pokles membránového potenciálu. Celková respirace v ovlivněných buňkách poklesla pouze o 20 %, jelikož trypanosomí alternativní oxidáza efektivně nahradila chybějící cytochromy a stala se hlavní koncovou oxidázou. (cs) MRP1 and MRP2 are multifunctional mitochondrial RNA-binding proteins with a regulatory role in RNA editing and putative role(s) in RNA processing in Trypanosoma brucei. Silencing of MRP1 and/or MRP2 by RNA interference affected the assembly and functionality of respiratory complexes. The absence of several subunits of complexes I, III and IV resulted in their disintegration and subsequent decrease of specific activities and also caused a significant decrease of membrane potential. The overall respiration in the interfered cells decreased by only about 20%, since the trypanosome alternative oxidase effectively replaced the missing cytochromes and became the principal terminal oxidase. MRP1 and MRP2 are multifunctional mitochondrial RNA-binding proteins with a regulatory role in RNA editing and putative role(s) in RNA processing in Trypanosoma brucei. Silencing of MRP1 and/or MRP2 by RNA interference affected the assembly and functionality of respiratory complexes. The absence of several subunits of complexes I, III and IV resulted in their disintegration and subsequent decrease of specific activities and also caused a significant decrease of membrane potential. The overall respiration in the interfered cells decreased by only about 20%, since the trypanosome alternative oxidase effectively replaced the missing cytochromes and became the principal terminal oxidase. (en)
Title	The effect of down-regulation of mitochondrial RNA-binding proteins MRP1 and MRP2 on respiratory complexes in procyclic Trypanosoma brucei Vliv potlačení mitochondriálních RNA-vážících proteinů MRP1 a MRP2 na dýchací komplexy procyklického stádia Trypanosoma brucei (cs) The effect of down-regulation of mitochondrial RNA-binding proteins MRP1 and MRP2 on respiratory complexes in procyclic Trypanosoma brucei (en)
skos:prefLabel	The effect of down-regulation of mitochondrial RNA-binding proteins MRP1 and MRP2 on respiratory complexes in procyclic Trypanosoma brucei Vliv potlačení mitochondriálních RNA-vážících proteinů MRP1 a MRP2 na dýchací komplexy procyklického stádia Trypanosoma brucei (cs) The effect of down-regulation of mitochondrial RNA-binding proteins MRP1 and MRP2 on respiratory complexes in procyclic Trypanosoma brucei (en)
skos:notation	RIV/60077344:_____/06:00048924!RIV07-AV0-60077344
http://linked.open.../vavai/riv/strany	65;73
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GA204/06/1558), P(IAA5022302), S, Z(AV0Z60220518), Z(MSM6007665801)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Jirků, Milan Horáková, Eva Lukeš, Julius Zíková, Alena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	473031
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/06:00048924
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	RNA-binding protein; RNA interference; mitochondrial respiratory chain (en)
http://linked.open.../riv/klicoveSlovo	RNA interference RNA-binding protein mitochondrial respiratory chain
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[3E9876281EA6]
http://linked.open...i/riv/nazevZdroje	Molecular and Biochemical Parasitology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Functional analysis of mitochondrial proteins in Trypanosoma brucei Functional analysis of candidate components of the RNA editing machinery in the flagellate Trypanosoma brucei
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	149
http://linked.open...iv/tvurceVysledku	Jirků, Milan Lukeš, Julius Zíková, Alena Horáková, Eva Dunajčíková, P.
http://linked.open...n/vavai/riv/zamer	Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni EKOLOGICKÉ, EVOLUČNÍ A EXPERIMENTÁLNĚ BIOLOGICKÉ PŘÍSTUPY KE STUDIU VZNIKU A VÝZNAMU BIODIVERZITY
issn	0166-6851
number of pages	9 (xsd:int)
is http://linked.open...avai/riv/vysledek of	The effect of down-regulation of mitochondrial RNA-binding proteins MRP1 and MRP2 on respiratory complexes in procyclic Trypanosoma brucei The effect of down-regulation of mitochondrial RNA-binding proteins MRP1 and MRP2 on respiratory complexes in procyclic Trypanosoma brucei

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