About: Activation of insect anti-oxidative mechanisms by mammalian glucagon

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Resembling the main function of insect adipokinetic hormones (AKHs), the vertebrate hormone glucagon mobilizes energy reserves and participates in the control of glucose level in the blood. Considering the similarities, the effect of porcine glucagon was evaluated in an insect model species, the firebug Pyrrhocoris apterus. Using the mouse anti-glucagon antibody, presence of immunoreactive material was demonstrated for the first time in the firebug CNS and gut by ELIS. Mammalian (porcine) glucagon injected into the adult bugs showed no effect on hemolymph lipid level or on the level of AKH in CNS and hemolymph, however, it activated an antioxidant response when oxidative stress was elicited by paraquat, a diquaternary derivative of 4, 4'-bipyridyl. Glucagon elicited the antioxidant response by increasing glutathione and decreasing protein carbonyl levels in hemolymph, decreasing both protein carbonyl and protein nitrotyrosine levels in CNS. Additionally, when co-injected with paraquat, glucagon p Resembling the main function of insect adipokinetic hormones (AKHs), the vertebrate hormone glucagon mobilizes energy reserves and participates in the control of glucose level in the blood. Considering the similarities, the effect of porcine glucagon was evaluated in an insect model species, the firebug Pyrrhocoris apterus. Using the mouse anti-glucagon antibody, presence of immunoreactive material was demonstrated for the first time in the firebug CNS and gut by ELIS. Mammalian (porcine) glucagon injected into the adult bugs showed no effect on hemolymph lipid level or on the level of AKH in CNS and hemolymph, however, it activated an antioxidant response when oxidative stress was elicited by paraquat, a diquaternary derivative of 4, 4'-bipyridyl. Glucagon elicited the antioxidant response by increasing glutathione and decreasing protein carbonyl levels in hemolymph, decreasing both protein carbonyl and protein nitrotyrosine levels in CNS. Additionally, when co-injected with paraquat, glucagon p (en)
Title	Activation of insect anti-oxidative mechanisms by mammalian glucagon Activation of insect anti-oxidative mechanisms by mammalian glucagon (en)
skos:prefLabel	Activation of insect anti-oxidative mechanisms by mammalian glucagon Activation of insect anti-oxidative mechanisms by mammalian glucagon (en)
skos:notation	RIV/60076658:12310/09:00010483!RIV10-MSM-12310___
http://linked.open...avai/riv/aktivita	P V Z
http://linked.open...avai/riv/aktivity	P(GA522/07/0788), V, Z(AV0Z50070508)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Kodrík, Dalibor
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Jihočeská univerzita v Českých Budějovicích / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	301835
http://linked.open...ai/riv/idVysledku	RIV/60076658:12310/09:00010483
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	PYRRHOCORIS-APTERUS L.; MANDUCA-SEXTA L; ADIPOKINETIC HORMONE; OXIDATIVE STRESS; GLUTATHIONE SYNTHESIS; SIGNAL-TRANSDUCTION; HEPATIC GLUTATHIONE; MODIFIED PROTEINS; CORPORA CARDIACA; APIS-MELLIFICA (en)
http://linked.open.../riv/klicoveSlovo	ADIPOKINETIC HORMONE APIS-MELLIFICA CORPORA CARDIACA GLUTATHIONE SYNTHESIS MANDUCA-SEXTA L MODIFIED PROTEINS PYRRHOCORIS-APTERUS L. OXIDATIVE STRESS SIGNAL-TRANSDUCTION HEPATIC GLUTATHIONE
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[DFC7FB8AAEA8]
http://linked.open...i/riv/nazevZdroje	Comparative Biochemistry and Physiology B
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of insect neurohormones as potential biorationale pesticides
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	152
http://linked.open...iv/tvurceVysledku	Kodrík, Dalibor Socha, Radomír Alquicer, Glenda Večeřa, Josef Krishnan, Natraj
http://linked.open...ain/vavai/riv/wos	000263817500004
http://linked.open...n/vavai/riv/zamer	Study of the regulation of insect organism, dynamics of insect populations and function of insects in ecosystems
issn	0305-0491
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	12310
is http://linked.open...avai/riv/vysledek of	Activation of insect anti-oxidative mechanisms by mammalian glucagon Activation of insect anti-oxidative mechanisms by mammalian glucagon Activation of insect anti-oxidative mechanisms by mammalian glucagon Activation of insect anti-oxidative mechanisms by mammalian glucagon

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