About: Stabilization of the beta-hairpin in Mason-Pfizer monkey virus capsid protein- a critical step for infectivity

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About: Stabilization of the beta-hairpin in Mason-Pfizer monkey virus capsid protein- a critical step for infectivity Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.retrovirology.com/content/11/1/94
Description	Background: Formation of a mature core is a crucial event for infectivity of retroviruses such as Mason-Pfizer monkey virus (M-PMV). The process is triggered by proteolytic cleavage of the polyprotein precursor Gag, which releases matrix, capsid (CA), and nucleocapsid proteins. Once released, CA assembles to form a mature core - a hexameric lattice protein shell that protects retroviral genomic RNA. Subtle conformational changes within CA induce the transition from the immature lattice to the mature lattice. Upon release from the precursor, the initially unstructured N-terminus of CA is refolded to form a beta-hairpin stabilized by a salt bridge between the N-terminal proline and conserved aspartate. Although the crucial role of the beta-hairpin in the mature core assembly has been confirmed, its precise structural function remains poorly understood. Background: Formation of a mature core is a crucial event for infectivity of retroviruses such as Mason-Pfizer monkey virus (M-PMV). The process is triggered by proteolytic cleavage of the polyprotein precursor Gag, which releases matrix, capsid (CA), and nucleocapsid proteins. Once released, CA assembles to form a mature core - a hexameric lattice protein shell that protects retroviral genomic RNA. Subtle conformational changes within CA induce the transition from the immature lattice to the mature lattice. Upon release from the precursor, the initially unstructured N-terminus of CA is refolded to form a beta-hairpin stabilized by a salt bridge between the N-terminal proline and conserved aspartate. Although the crucial role of the beta-hairpin in the mature core assembly has been confirmed, its precise structural function remains poorly understood. (en)
Title	Stabilization of the beta-hairpin in Mason-Pfizer monkey virus capsid protein- a critical step for infectivity Stabilization of the beta-hairpin in Mason-Pfizer monkey virus capsid protein- a critical step for infectivity (en)
skos:prefLabel	Stabilization of the beta-hairpin in Mason-Pfizer monkey virus capsid protein- a critical step for infectivity Stabilization of the beta-hairpin in Mason-Pfizer monkey virus capsid protein- a critical step for infectivity (en)
skos:notation	RIV/00216224:14740/14:00077815!RIV15-MSM-14740___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0068), P(GA14-15326S), P(LO1302)
http://linked.open...iv/cisloPeriodika	October 2014
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Žídek, Lukáš Papoušková, Veronika
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	46991
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/14:00077815
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	N-TERMINAL DOMAIN; IN-VITRO; STRUCTURAL-ANALYSIS; ESCHERICHIA-COLI; GAG POLYPROTEIN; CORE FORMATION; RESOLUTION; MATURATION; ASSIGNMENT; MUTATIONS (en)
http://linked.open.../riv/klicoveSlovo	ESCHERICHIA-COLI IN-VITRO MUTATIONS MATURATION RESOLUTION ASSIGNMENT CORE FORMATION GAG POLYPROTEIN N-TERMINAL DOMAIN STRUCTURAL-ANALYSIS
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[0ED3224AA97C]
http://linked.open...i/riv/nazevZdroje	Retrovirology
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology InterBioMed Study of structure and interactions critical for formation of immature retroviral particles for testing and rational design of HIV assembly inhibitors
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	11
http://linked.open...iv/tvurceVysledku	Papoušková, Veronika Žídek, Lukáš Hrabal, Richard Ruml, Tomáš Rumlová, Michaela Křížová, Ivana Doležal, Michal Hadravová, Romana Obr, Martin
http://linked.open...ain/vavai/riv/wos	000344571100001
issn	1742-4690
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.1186/s12977-014-0094-8
http://localhost/t...ganizacniJednotka	14740

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