About: A combined approach for the study of histone deacetylase inhibitors

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://pubs.rsc.org/en/Content/ArticleLanding/2012/MB/c2mb25136a
Description	Overexpression of histone deacetylases (HDACs), with consequent hypoacetylation of histones, is reportedly associated with transcriptional repression of tumour suppressor genes. Thus, inhibition of HDACs has emerged as a promising strategy in cancer therapy. In order to monitor the effects of potential HDAC inhibitors, a multi-level approach consisting of preliminary screening (measurement of HDAC activity and semi-quantitative evaluation of histone H4 modification profile by MALDI-TOF MS) and detailed analysis of histone modification forms (using 2-D AUT/AU PAGE and LC-ESI-IT MS) has been used in this study. The data obtained provide a global insight into the effects of HDAC inhibitors on the histone acetylation status that participates in gene transcription control. Overexpression of histone deacetylases (HDACs), with consequent hypoacetylation of histones, is reportedly associated with transcriptional repression of tumour suppressor genes. Thus, inhibition of HDACs has emerged as a promising strategy in cancer therapy. In order to monitor the effects of potential HDAC inhibitors, a multi-level approach consisting of preliminary screening (measurement of HDAC activity and semi-quantitative evaluation of histone H4 modification profile by MALDI-TOF MS) and detailed analysis of histone modification forms (using 2-D AUT/AU PAGE and LC-ESI-IT MS) has been used in this study. The data obtained provide a global insight into the effects of HDAC inhibitors on the histone acetylation status that participates in gene transcription control. (en)
Title	A combined approach for the study of histone deacetylase inhibitors A combined approach for the study of histone deacetylase inhibitors (en)
skos:prefLabel	A combined approach for the study of histone deacetylase inhibitors A combined approach for the study of histone deacetylase inhibitors (en)
skos:notation	RIV/00216224:14740/12:00060968!RIV13-MSM-14740___
http://linked.open...avai/predkladatel	Středoevropský technologický institut
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(2B08060), P(ED1.1.00/02.0068)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Nováková, Kateřina Zdráhal, Zbyněk Fajkus, Jiří Fajkusová, Lenka Činčárová, Lenka Lochmanová, Gabriela Šilerová, Pavla Konečná, Hana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	120066
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/12:00060968
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	histone acetylation; inhibitors of histone deacetylases; MALDI-MS; LC-MS/MS (en)
http://linked.open.../riv/klicoveSlovo	LC-MS/MS MALDI-MS histone acetylation inhibitors of histone deacetylases
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[37ECB5376C46]
http://linked.open...i/riv/nazevZdroje	Molecular BioSystems
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology Development of diagnostics and treatment of serious heart and vascular diseases using genomic and proteomic approaches
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	8
http://linked.open...iv/tvurceVysledku	Fajkusová, Lenka Konečná, Hana Nováková, Kateřina Zdráhal, Zbyněk Fajkus, Jiří Lochmanová, Gabriela Činčárová, Lenka Šilerová, Pavla
http://linked.open...ain/vavai/riv/wos	000309481300017
issn	1742-206X
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1039/c2mb25136a
http://localhost/t...ganizacniJednotka	14740
is http://linked.open...avai/riv/vysledek of	A combined approach for the study of histone deacetylase inhibitors

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