About: Dexamethasone and Insulin Affecting SFTPA1 and SFTPA2 mRNA Levels

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Lung surfactants primary function is to lower surface tension and therefore it protects alveoli from collapsing. It consists of phospholipids and four proteins. These proteins stabilize the surfactant layer (SFTPB and SFTPC) and modulate immunological response to various pathogens (SFTPA, SFTPD), which is the secondary role of lung surfactant. Low levels of surfactant proteins lead to severe diseases. Dexamethasone and insulin were applied on H441 cell line. This cell line resembles Clara cells and therefore serves as a model of lung surfactant producing cells. SFTPA1 (and its analog SFTPA2) were not affected by insulin (2500 ng/mL), but dexamethasone treatment (10-7 M) for 48 hours resulted in 50% decrease in their mRNA production. Surprisingly, combination of dexamethasone and insulin resulted in 90% decrease. Lung surfactants primary function is to lower surface tension and therefore it protects alveoli from collapsing. It consists of phospholipids and four proteins. These proteins stabilize the surfactant layer (SFTPB and SFTPC) and modulate immunological response to various pathogens (SFTPA, SFTPD), which is the secondary role of lung surfactant. Low levels of surfactant proteins lead to severe diseases. Dexamethasone and insulin were applied on H441 cell line. This cell line resembles Clara cells and therefore serves as a model of lung surfactant producing cells. SFTPA1 (and its analog SFTPA2) were not affected by insulin (2500 ng/mL), but dexamethasone treatment (10-7 M) for 48 hours resulted in 50% decrease in their mRNA production. Surprisingly, combination of dexamethasone and insulin resulted in 90% decrease. (en)
Title	Dexamethasone and Insulin Affecting SFTPA1 and SFTPA2 mRNA Levels Dexamethasone and Insulin Affecting SFTPA1 and SFTPA2 mRNA Levels (en)
skos:prefLabel	Dexamethasone and Insulin Affecting SFTPA1 and SFTPA2 mRNA Levels Dexamethasone and Insulin Affecting SFTPA1 and SFTPA2 mRNA Levels (en)
skos:notation	RIV/00216224:14330/10:00045383!RIV11-MSM-14330___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(2B06052), Z(MSM0021622430)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Doležel, Jan Potěšilová, Michaela Vaňhara, Petr Ručka, Zdeněk Stejskal, Stanislav Krontorád Koutná, Irena Tesařová, Lenka
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	254040
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/10:00045383
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Lung surfactant; Insulin; Dexamethasone (en)
http://linked.open.../riv/klicoveSlovo	Dexamethasone Insulin Lung surfactant
http://linked.open...ontrolniKodProRIV	[31D229F878C6]
http://linked.open...v/mistoKonaniAkce	Brno, Česká Republika
http://linked.open...i/riv/mistoVydani	Brno, Česká republika
http://linked.open...i/riv/nazevZdroje	Advances in Molecular and Cancer Biology, 2010
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Determination of markers, screening and early diagnostics of cancer diseases using highly automated processing of multidimensional biomedical images
http://linked.open...UplatneniVysledku	2010
http://linked.open...iv/tvurceVysledku	Doležel, Jan Potěšilová, Michaela Stejskal, Stanislav Krontorád Koutná, Irena Tesařová, Lenka Vaňhara, Petr Ručka, Zdeněk
http://linked.open...vavai/riv/typAkce	EUR - Evropská
http://linked.open.../riv/zahajeniAkce	2010-11-11 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
number of pages	3 (xsd:int)
http://purl.org/ne...btex#hasPublisher	muni PRESS
https://schema.org/isbn	978-80-210-5312-0
http://localhost/t...ganizacniJednotka	14330
is http://linked.open...avai/riv/vysledek of	Dexamethasone and Insulin Affecting SFTPA1 and SFTPA2 mRNA Levels Dexamethasone and Insulin Affecting SFTPA1 and SFTPA2 mRNA Levels Dexamethasone and Insulin Affecting SFTPA1 and SFTPA2 mRNA Levels

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