About: Representation of T-cell receptor V beta families detected by reverse transcription PCR and capillary electrophoresis

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About: Representation of T-cell receptor V beta families detected by reverse transcription PCR and capillary electrophoresis Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	It has been demonstrated in many recent studies that monitoring the T-cell population diversity is important when evaluating an individual immune status in various clinical condition, including haematopoietic stem cell transplantation, cancer, or infectious and autoimmune diseases. Analyses of T-cell receptor VB families (VB families) are most often performed to examine this diversity and the trend is to make the methodology more specific and easy to use. The aim of our study was to join this effort and to establish a method for specific and simple determination of the VB family usage. Reverse transcription PCR which allows detecting of all VB family members was combined with capillary electrophoresis in the Agilent 2100 Bioanalyzer in order to determine the relative expression values of VB families in PBMC population. Healthy donors were characterized by expression of all VB families tested, while multiple myeloma patients showed zero expression of several VB families. It has been demonstrated in many recent studies that monitoring the T-cell population diversity is important when evaluating an individual immune status in various clinical condition, including haematopoietic stem cell transplantation, cancer, or infectious and autoimmune diseases. Analyses of T-cell receptor VB families (VB families) are most often performed to examine this diversity and the trend is to make the methodology more specific and easy to use. The aim of our study was to join this effort and to establish a method for specific and simple determination of the VB family usage. Reverse transcription PCR which allows detecting of all VB family members was combined with capillary electrophoresis in the Agilent 2100 Bioanalyzer in order to determine the relative expression values of VB families in PBMC population. Healthy donors were characterized by expression of all VB families tested, while multiple myeloma patients showed zero expression of several VB families. (en)
Title	Representation of T-cell receptor V beta families detected by reverse transcription PCR and capillary electrophoresis Representation of T-cell receptor V beta families detected by reverse transcription PCR and capillary electrophoresis (en)
skos:prefLabel	Representation of T-cell receptor V beta families detected by reverse transcription PCR and capillary electrophoresis Representation of T-cell receptor V beta families detected by reverse transcription PCR and capillary electrophoresis (en)
skos:notation	RIV/00216224:14330/09:00036623!RIV10-MSM-14330___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(2B06052), P(LC535), Z(MSM0021622430)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Potěšilová, Michaela Stejskal, Stanislav Krontorád Koutná, Irena Tesařová, Lenka Peterková, Martina Dvořáková, Magdaléna
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	339014
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/09:00036623
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	T cells - V beta gene families - reverse transcription PCR - capillary electrophoresis (en)
http://linked.open.../riv/klicoveSlovo	T cells
http://linked.open...ontrolniKodProRIV	[474A7EC2AC3C]
http://linked.open...v/mistoKonaniAkce	Athens, Greece
http://linked.open...i/riv/mistoVydani	University of Nevada, USA
http://linked.open...i/riv/nazevZdroje	Experimental Hematology, Volume 37, Number 9
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Determination of markers, screening and early diagnostics of cancer diseases using highly automated processing of multidimensional biomedical images Chromosome dynamics and organization during the cell cycle in normal and pathologic conditions
http://linked.open...UplatneniVysledku	2009
http://linked.open...iv/tvurceVysledku	Potěšilová, Michaela Stejskal, Stanislav Krontorád Koutná, Irena Tesařová, Lenka Peterková, Martina Dvořáková, Magdaléna
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open...ain/vavai/riv/wos	000269396400144
http://linked.open.../riv/zahajeniAkce	2009-01-01 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	0301-472X
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Elsevier
http://localhost/t...ganizacniJednotka	14330
is http://linked.open...avai/riv/vysledek of	Representation of T-cell receptor V beta families detected by reverse transcription PCR and capillary electrophoresis Representation of T-cell receptor V beta families detected by reverse transcription PCR and capillary electrophoresis Representation of T-cell receptor V beta families detected by reverse transcription PCR and capillary electrophoresis Representation of T-cell receptor V beta families detected by reverse transcription PCR and capillary electrophoresis

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