About: Relationship between circulating levels of soluble RAGE (sRAGE) and genetic variability in the AGER gene in subjects with diabetic nephropathy     Goto   Sponge   NotDistinct   Permalink

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  • RAGE2 haplotype was previously identified as a genetic risk factor for the development and early onset of diabetic nephropathy. Curent study showed that (i) sRAGE significantly differed among subjects bearing variable number of RAGE2 haplotype copies, (ii) was significantly higher in subjects with nephropathy than normoalbuminuric patients and (iii) positively correlated with severity of nephropathy, S-urea, S-creatinine and negatively with glomerular filtration rate (GFR). GFR seems to be principal determinant of the AGE and sRAGE levels.
  • RAGE2 haplotype was previously identified as a genetic risk factor for the development and early onset of diabetic nephropathy. Curent study showed that (i) sRAGE significantly differed among subjects bearing variable number of RAGE2 haplotype copies, (ii) was significantly higher in subjects with nephropathy than normoalbuminuric patients and (iii) positively correlated with severity of nephropathy, S-urea, S-creatinine and negatively with glomerular filtration rate (GFR). GFR seems to be principal determinant of the AGE and sRAGE levels. (en)
Title
  • Relationship between circulating levels of soluble RAGE (sRAGE) and genetic variability in the AGER gene in subjects with diabetic nephropathy
  • Relationship between circulating levels of soluble RAGE (sRAGE) and genetic variability in the AGER gene in subjects with diabetic nephropathy (en)
skos:prefLabel
  • Relationship between circulating levels of soluble RAGE (sRAGE) and genetic variability in the AGER gene in subjects with diabetic nephropathy
  • Relationship between circulating levels of soluble RAGE (sRAGE) and genetic variability in the AGER gene in subjects with diabetic nephropathy (en)
skos:notation
  • RIV/00216224:14330/06:00015337!RIV10-MSM-14330___
http://linked.open...avai/riv/aktivita
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  • P(KJB501620601), Z(MSM0021620807)
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  • 497075
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  • RIV/00216224:14330/06:00015337
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  • diabetic nephropathy; RAGE; polymorphism; sRAGE; renal failure (en)
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  • [0DE475485656]
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  • Hertlová, Miluše
  • Kalousová, Marta
  • Zima, Tomáš
  • Kaňková, Kateřina
  • Krusová, Darja
http://linked.open...n/vavai/riv/zamer
http://localhost/t...ganizacniJednotka
  • 14330
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