About: Nuclear topography of the c-myc gene in human leukemic cells

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	myc gene plays an essential role in the regulation of the cell cycle and differentiation. Therefore, changes of the c-myc positioning during differentiation are of great interest. As a model system of cell differentiation, the HL-60 and U-937 human leukemic cell lines, were used in our experiments. These cells can be induced to differentiation into granulocytes that represent one of the pathways of blood cell maturation. In this study, changes of the topographic characteristics of the c-myc gene (8q24), centromeric region of chromosome 8 and chromosome 8 domain during differentiation of HL-60 and U-937 cells were detected using fluorescence in situ hybridisation (FISH). FISH techniques and fluorescence microscopy combined with image acquisition and analysis (High Resolution Cytometry) were used in order to detect the topographic features of nuclear chromatin. myc gene plays an essential role in the regulation of the cell cycle and differentiation. Therefore, changes of the c-myc positioning during differentiation are of great interest. As a model system of cell differentiation, the HL-60 and U-937 human leukemic cell lines, were used in our experiments. These cells can be induced to differentiation into granulocytes that represent one of the pathways of blood cell maturation. In this study, changes of the topographic characteristics of the c-myc gene (8q24), centromeric region of chromosome 8 and chromosome 8 domain during differentiation of HL-60 and U-937 cells were detected using fluorescence in situ hybridisation (FISH). FISH techniques and fluorescence microscopy combined with image acquisition and analysis (High Resolution Cytometry) were used in order to detect the topographic features of nuclear chromatin. (en)
Title	Nuclear topography of the c-myc gene in human leukemic cells Nuclear topography of the c-myc gene in human leukemic cells (en)
skos:prefLabel	Nuclear topography of the c-myc gene in human leukemic cells Nuclear topography of the c-myc gene in human leukemic cells (en)
skos:notation	RIV/00216224:14330/00:00001989!RIV/2002/GA0/143302/N
http://linked.open.../vavai/riv/strany	1
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA202/97/0874), P(GA202/98/P253), P(NM15), P(VS97031), Z(MSM 143300002)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2002
http://linked.open...aciTvurceVysledku	Kozubek, Michal Gajdušková, Pavla Cafourková, Alena Bártová, Eva Kozubek, Stanislav Krontorád Koutná, Irena Lukášová, Emilie Skalníková, Magdalena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	719724
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/00:00001989
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	c-myc topography; differentiation; FISH; HL-60; U-937 (en)
http://linked.open.../riv/klicoveSlovo	HL-60 FISH differentiation U-937 c-myc topography
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[9A8C43E9275C]
http://linked.open...i/riv/nazevZdroje	Gene
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	The structure of interphase nucleus and its changes after irradiation Changes in the structure of interphase nucleai of human leukemic cell lines after treatment with differentiating agents and gama irradiation The use interphase FISH for the determination of individuals with elevated risk of the induction of hemoblastoses Image analysis in the study of mechanisms of induction, in diagnosis and for prevention of deleterious human diseases
http://linked.open...UplatneniVysledku	2000
http://linked.open...v/svazekPeriodika	244
http://linked.open...iv/tvurceVysledku	Bártová, Eva Kozubek, Stanislav Lukášová, Emilie Kozubek, Michal Koutná, Irena Skalníková, Magdalena Jirsová, Pavla Gaňová, Alena
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20143300002
issn	0378-1119
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	14330

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