About: Characterization of host-range mutations in genomes of Staphylococcus Twortlikeviruses

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About: Characterization of host-range mutations in genomes of Staphylococcus Twortlikeviruses Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The emergence and alarming increase of multiresistant strains of Staphylococcus aureus emphasizes the need for new and innovative antimicrobial strategies. Polyvalent bacteriophages from the family Myoviridae, sub-family Spounavirinae of genus Twort-like phages that infect S. aureus have potential for use in phage therapy. In this study we characterized genomic sequences of the polyvalent staphylococcal phage 812 and its spontaneous host-range mutants selected on non-susceptible S. aureus strains. The wild type phage was shown to lyse up to 65%, whereas host-range mutants up to 95% of S. aureus strains under study. Genomic DNAs of five phages were sequenced using 454 Genome Sequencer Junior (Roche). Bacteriophage DNA sequences were assembled by software GS De novo Assembler and GS Reference Mapper (Roche). Genome of phage K was chosen as the reference. The emergence and alarming increase of multiresistant strains of Staphylococcus aureus emphasizes the need for new and innovative antimicrobial strategies. Polyvalent bacteriophages from the family Myoviridae, sub-family Spounavirinae of genus Twort-like phages that infect S. aureus have potential for use in phage therapy. In this study we characterized genomic sequences of the polyvalent staphylococcal phage 812 and its spontaneous host-range mutants selected on non-susceptible S. aureus strains. The wild type phage was shown to lyse up to 65%, whereas host-range mutants up to 95% of S. aureus strains under study. Genomic DNAs of five phages were sequenced using 454 Genome Sequencer Junior (Roche). Bacteriophage DNA sequences were assembled by software GS De novo Assembler and GS Reference Mapper (Roche). Genome of phage K was chosen as the reference. (en)
Title	Characterization of host-range mutations in genomes of Staphylococcus Twortlikeviruses Characterization of host-range mutations in genomes of Staphylococcus Twortlikeviruses (en)
skos:prefLabel	Characterization of host-range mutations in genomes of Staphylococcus Twortlikeviruses Characterization of host-range mutations in genomes of Staphylococcus Twortlikeviruses (en)
skos:notation	RIV/00216224:14310/14:00073314!RIV15-MSM-14310___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(EE2.4.31.0155), P(TA01010405)
http://linked.open...iv/cisloPeriodika	S1
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Benešík, Martin Doškař, Jiří Pantůček, Roman Mašlaňová, Ivana Varga, Marian
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	6944
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/14:00073314
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	bacteriophage therapy; Staphylococcus aureus; Twortlikevirus (en)
http://linked.open.../riv/klicoveSlovo	Staphylococcus aureus bacteriophage therapy Twortlikevirus
http://linked.open...odStatuVydavatele	RU - Ruská federace
http://linked.open...ontrolniKodProRIV	[51E4C02E7A7E]
http://linked.open...i/riv/nazevZdroje	Russian Journal of Infection and Immunity
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Research of broad host-range mutants of staphylococcal bacteriophages Partnerství a sítě pro spolupráci v experimentální biologii
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	4
http://linked.open...iv/tvurceVysledku	Benešík, Martin Boštík, Josef Doškař, Jiří Moša, Marek Pantůček, Roman Mašlaňová, Ivana Varga, Marian
issn	2220-7619
number of pages	2 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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